The effectiveness of intrauterine infusion of autologous platelet-rich plasma versus granulocyte colony-stimulating factor in repeated implantation failure patients: An unblinded randomized clinical trial

Articles in Press

Document Type : Original Article

Authors

1 Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran

2 1. Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran 2. Department of Animal Science, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran

3 Mehr Medical Institute, Ershad St., Shahid Ansari Blvd., Rasht, Iran

10.22074/ijfs.2024.2013900.1557

Abstract

Background: Repeated implantation failure (RIF) refers to the condition wherein embryos of high quality are unable to successfully implant after undergoing multiple cycles of in vitro fertilization (IVF) treatment. The aim of this study was to investigate how the use of intrauterine granulocyte colony-stimulating factor (G-CSF) and platelet-rich plasma (PRP) affects the rate of ongoing pregnancy in patients with RIF.

Materials and Methods: The present prospective randomized clinical trial study was conducted at the IVF center of Mehr Medical Institute in Rasht, Iran, from 2020 to 2022. The research consisted of 200 individuals who had experienced multiple failed cycles. These patients were randomized into two groups: intrauterine infusion of 1 ml of G-CSF and intrauterine infusion of 1ml autologous PRP at least 48 hours before embryo transfer. The groups were compared in terms of implantation rates, chemical, clinical, and ongoing pregnancy.

Results: The implantation rate was significantly higher in patients who received PRP (0.17±0.29 vs. 0.08±0.2, P = 0.011). Chemical pregnancy in the PRP group was significantly higher than G-CSF group (36.7% vs. 17.4%, P = 0.003). Moreover, both clinical pregnancy and ongoing pregnancy rates were significantly higher in the PRP group compared to the G-CSF group (33.7% vs. 13% and 27.6% vs. 13%, P = 0.001, P-value = 0.02 respectively).

Conclusion: We showed that the utilization of PRP via intrauterine infusion is considerably more successful than G-CSF in enhancing pregnancy and live birth rates among patients with RIF.

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International Journal of Fertility and Sterility

Articles in Press, Accepted Manuscript
Available Online from 21 February 2024

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