Document Type : Original Article
Authors
1
Imam Reza Hospital, Imam Reza St., Mashhad, Iran
2
, Department of Obstetrics & Gynecology,,School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
3
Independent researcher ,Department of Industrial Engineering, Yazd University, Yazd,Iran
4
MD, Mashhad University of Medical Sciences, Mashhad, Iran
5
Assistant Professor of Nursing, Department of pediatrics,School of Nursing And Midwifery, Nursing and Midwifery Care,Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
10.22074/ijfs.2023.2000574.1463
Abstract
Background:
Over the past years, transfer in the blastocyst stage has been developed which has been claimed to improve pregnancy outcomes. The aim of this study is to evaluate the pregnancy results between blastocyst stage embryo transfer and cleavage stage embryo transfer in the fresh cycle.
Materials and Methods: This randomized clinical trial study was performed on 240 infertile women in the infertility research center of Milad Hospital in Mashhad, Iran during 2018-2020. This research involves the participation of patients who are undergoing their first intra-cytoplasmic sperm injection (ICSI) procedure. These patients have been assigned to either undergo cleavage embryo transfer (N=112) or blastocyst stage transfer (n=107) . Pregnancy outcomes were measured in both groups.
Results: There was no difference regarding age, BMI, serum FSH, duration of infertility, and etiology of infertility between the two groups (p >0.05 ). The number of follicles, and total oocytes M2 oocytes were higher in the blastocyst stages. A considerably more mean number of embryos was transferred at the cleavage stage in comparison to the number of transferred blastocysts (p=0.001).The blastocyst arm had more vitrified embryos than those in the cleavage arm (p=0.000). Although the rate of implantation (p=0.332) chemical pregnancy (p=0.165), clinical pregnancy (p=0.694) and live berth (p=0.727) were higher in blastocysts it is, no significant differences. The rate of abortion also was higher in blastocysts but it was no significant difference (p=0.296).
Conclusions: The transfer of blastocysts in the fresh cycle during the intracytoplasmic sperm injection (ICSI) cycle may confer greater advantages compared to the transfer of cleavage embryos.
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