The Effect of Adding Daily 50 milligram Intramuscular Progesterone to 800 milligram Progesterone Suppository on the In vitro fertilization Success Rate in Women with Low Progesterone Levels: A Clinical Trial Study

Articles in Press

Document Type : Original Article

Authors

1 Department of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.

3 Tehran university of medical sciences

4 Department of Obstetrics and Gynecology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

5 TUMS

10.22074/ijfs.2023.2008438.1506

Abstract

Background: Since low progesterone level on the embryo transfer day significantly reduces the pregnancy rate, the present study was conducted with the aim of investigating the effect of adding daily 50 milligram (mg) intramuscular progesterone to 800 mg progesterone suppository on the in vitro fertilization (IVF) success rate in women with low progesterone levels.

Materials and Methods: This parallel open-label clinical trial was performed on 218 IVF candidate infertile women with less than 9.2 nanogram/milliliter progesterone level at the embryo transfer day. These women were randomized to the intervention or control groups using the randomization allocation rule . In the intervention group, from the day of embryo transfer, 50 mg progesterone was prescribed intramuscularly once a day in addition to 400 mg progesterone suppository every 12 hours. While in the control group, only 400 mg progesterone suppositories were prescribed every 12 hours. In the case of pregnancy, the drugs above were continued until 12 weeks after the embryo transfer.

Results: Clinical pregnancy occurred in 54 (50.0%) women in the intervention group, and only 39 (36.8%) women in the control group, which was significantly different (p=0.035). Ongoing pregnancy occurred in 47 (43.5%) women in the intervention group, and only 33 (31.1%) women in the control group, which was significantly different (p=0.042). In addition, there were no significant differences regards abortion and multiple pregnancy rates between the two groups.

Conclusion: The present study showed that intramuscular injection of 50 mg progesterone significantly increases the clinical and ongoing pregnancy rates.

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International Journal of Fertility and Sterility

Articles in Press, Accepted Manuscript
Available Online from 21 October 2023

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