Document Type : Systematic Review
Authors
1
Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
2
PhD Student in Reproductive Health, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
3
PhD Student of Reproductive Health, Research Student Committee, Mashhad University of Medical Sciences, Mashhad, Iran
4
Professor, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5
Assistant Professor, Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22074/ijfs.2023.1987000.1421
Abstract
Semen quality is considered as an alternative measure for men's fertility. Several studies have examined the association between the hepatitis B virus (HBV) infection and semen quality, but the findings have been inconclusive. The present study investigated the effect of HBV on semen quality. This systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA), 2020 as well as Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guideline. In this study, electronic databases including PubMed, Web of Science, Scopus and Cochrane Library and also Persian databases including SID and Magiran were searched without time limit until the June 2023. All Cohort and Case-Control studies examining the effect of HBV infection on the semen parameters of infertile men were included in the study. Animal studies, letters to the editor and case reports were excluded. The Newcastle-Ottawa scale used to evaluate the quality of the included articles. Data analysis was done with Stata software. Of the 913 studies, 13 observational studies comprised a total of 10156 patients were included in this review, nine of which were included in the meta-analysis. The results showed that HBV infection has a negative effect on semen volume (95%CI:[-0.33, -0.09], P<0.001), sperm concentration (95%CI:[-8.53, -2.66], P<0.001), sperm motility (95%CI:[-10.06, -3.39], P<0.001), sperm normal morphology (95%CI:[-6.42, -1.06], P<0.001) and sperm viability (95%CI:[-11.64, -0.31], P<0.001). The results suggest that the HBV infection has negative effect on the semen quality in the infertile men. However, further research with more robust design is recommended.
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