Impact of COVID-19 Vaccination on IVF Outcomes: A Systematic Review

Articles in Press

Document Type : Systematic Review

Authors

1 Obstetrics and Gynecology Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

2 Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia; Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia

10.22074/ijfs.2023.1990160.1438

Abstract

Objective: Covid-19 vaccination, particularly vaccines that mimic the structure of the Covid-19 virus (mRNA vaccines), may be wrongly assumed to be disrupting factors affecting IVF outcome. This study aims to evaluate any significant impact of COVID-19 vaccination in women undergoing IVF to improve vaccine compliance and promote COVID-19 eradication.



Materials and Methods: This was a systematic review study. We searched studies published between 2020 and 2022 using databases such as PubMed, Cochrane, PMC, and CINAHL. Selected studies were carefully analyzed to review the impact of the COVID-19 vaccine on IVF outcomes.



Result: Seven retrospective and prospective cohort studies, which involved 3232 female patients undergoing IVF, whom also receiving full doses of COVID-19 vaccinations (mRNA), were included. All studies in the present review showed that despite presenting anti-SARS-CoV-2 antibodies after vaccination, there were no significant differences in IVF outcomes, implantation rates, and pregnancy rates. Contrary to the theory that presumed cross-reactivity between anti-SARS-CoV-2 antibodies and the human syncytin-1 protein could affect syncytiotrophoblast formation and embryo implantation.



Conclusion: The present review concluded that COVID-19 vaccination does not result in any detrimental effects on IVF outcomes and is safe for women undergoing IVF treatment. The results of our study are important to tackle misinformation regarding COVID-19 vaccination and infertility that caused vaccine hesitancy in women of reproductive age.



Keywords: SARS-CoV-2 virus, Covid-19 vaccine, mRNA vaccine, BNT16b2 vaccine, In Vitro Fertilization

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Main Subjects

International Journal of Fertility and Sterility

Articles in Press, Accepted Manuscript
Available Online from 12 September 2023

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