Document Type : Original Article
Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Kurmitola General Hospital, Dhaka, Bangladesh
Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Background: In individuals with coronavirus disease 2019 (COVID-19), male subjects have consistently been
linked to poor severity and prognosis. Data on sex hormones in non-critical COVID-19-infected patients are scarce.
The aim of this study was to assess the status of total testosterone (TT) and dehydroepiandrosterone sulfate (DHEAS)
among noncritical patients with COVID-19 according to sex and their associations with clinical and biochemical
Materials and Methods: This cross-sectional observational study was done in the COVID-19 unit of a University
hospital during the period of September 2021 to February 2022 among 91 adults (18-65 years) with reverse transcriptase-
polymerase chain reaction confirmed noncritical COVID-19 patients. Blood was drawn by venipuncture
before receiving steroids between 07:00 to 09:00 a.m. in a fasting state to measure serum TT and DHEAS by chemiluminescent
microparticle immunoassay. Diagnosis and classification of COVID-19 were done according to World
Health Organization’s interim guidance. Age- and sex-specific laboratory reference values were used to classify the
TT and DHEAS status of the patients.
Results: Only three males (8.1%) had low TT and the rest had normal TT. On the other hand, 15 (27.8%) of the females
had high TT with normal levels in the rest. Similarly, 11 (29.7%) males had low DHEAS. Females had low, normal,
and high DHEAS in four (7.4%), 48 (88.9%), and two (3.7%) cases respectively. Males with moderate severity of
COVID-19 had significantly lower DHEAS (post hoc P=0.038) than the mild group. Both TT (P=0.008) and DHEAS
(P=0.023) significantly correlated with neutrophils/lymphocytes ratio and only DHEAS with platelets/lymphocytes
ratio (P=0.044) in males. In females, TT significantly correlated with serum sodium (P=0.034).
Conclusion: In noncritical COVID-19 patients, substantial gender variations in TT and DHEAS were detected and
correlated with severity markers in males.