Department of Exercise Physiology, Ilam Branch. Islamic Azad University, Ilam, Iran.
10.22074/ijfs.2023.1987670.1427
Abstract
Abstract
Background: Central nervous system damage in multiple sclerosis (MS) leads to serious deficiencies. Sexual dysfunction and infertility in patients with MS have often been neglected in previous studies. Aerobic exercise is suggested to improves circulating testosterone levels, and sexual function. Therefore, the purpose of this study was to investigate the effect of aerobic exercise on sex hormones level in the Cuprizone rat model of MS.
Materials and Methods: In this experimental study, thirty male rats (aged 70 days, 154.55 ± 18.1 gr) were randomly divided in five groups, consisting of MS, exercise-MS (Ex-MS), MS-exercise (MS-Ex), exercise-MS-exercise (Ex-MS-EX), and normal control (control). MS was induced by feeding cuprizone pellets (0.2%) for 6 weeks. Exercise groups performed aerobic exercise protocol on a treadmill 5 days/week for 6 weeks before and during the induction of the MS model. The level of Testosterone, Follicle stimulating hormone (FSH), and Luteinizing hormone (LH) in the serum was measured using the ELISA method by standard kits (ZellBio Germany). Luxal fast blue staining (LFB) of the corpus callosum was performed.
Results: The results showed a significantly decreased in the serum levels of testosterone, FSH, and LH in the MS groups compared to the control group (p < 0.05). Furthermore, there was a significant increase in the serum levels of testosterone, FSH, and LH in the EX-MS-EX, and Ex-MS groups compared to the MS group (p < 0.05).
Conclusion: Aerobic exercise could improve the level of sex hormones in the Cuprizone rat model of MS and may be used to attenuate sexual dysfunction in patients with MS.
Abbasi, M., Farokhnezhad, M., Taheri Kalani, A., Lotfi, A., & Arghavanfar, H. (2023). Effects of aerobic training on sex hormones in the Cuprizone rat model of multiple sclerosis: An experimental study. International Journal of Fertility and Sterility, (), -. doi: 10.22074/ijfs.2023.1987670.1427
MLA
Maryam Abbasi; Mohammadtaghi Farokhnezhad; Abdolhosein Taheri Kalani; Ali reza Lotfi; Hadis Arghavanfar. "Effects of aerobic training on sex hormones in the Cuprizone rat model of multiple sclerosis: An experimental study". International Journal of Fertility and Sterility, , , 2023, -. doi: 10.22074/ijfs.2023.1987670.1427
HARVARD
Abbasi, M., Farokhnezhad, M., Taheri Kalani, A., Lotfi, A., Arghavanfar, H. (2023). 'Effects of aerobic training on sex hormones in the Cuprizone rat model of multiple sclerosis: An experimental study', International Journal of Fertility and Sterility, (), pp. -. doi: 10.22074/ijfs.2023.1987670.1427
VANCOUVER
Abbasi, M., Farokhnezhad, M., Taheri Kalani, A., Lotfi, A., Arghavanfar, H. Effects of aerobic training on sex hormones in the Cuprizone rat model of multiple sclerosis: An experimental study. International Journal of Fertility and Sterility, 2023; (): -. doi: 10.22074/ijfs.2023.1987670.1427
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