Optimizing Immature Testicular Tissue and Cell Transplantation Results: Comparing Transplantation Sites and Scaffolds

Document Type : Review Article


Department of Anatomical Sciences, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran


For patients who had testicular tissue cryopreserved before receiving gonadotoxic therapies, transplantation of testicular
tissues and cells has been recommended as a potential therapeutic option. There are no studies that indicate the
generation of sperm after human immature testicular tissue (ITT) or spermatogonial stem cells (SSCs) transplantation.
The use of releasing scaffolds and localized drug delivery systems as well as the optimizing transplantation site can
play an effective role in increasing the efficiency and improving the quality of testicular tissue and cell transplantation
in animal models. Current research is focused on optimizing ITT and cell transplantation, the use of releasing
scaffolds, and the selection of the right transplantation site that might restore sperm production or male infertility
treatment. By searching the PubMed and Google Scholar databases, original and review papers were collected. Search
terms were relevant for SSCs and tissue transplantation. In this review, we'll focus on the potential advantages of using
scaffolds and choosing the right transplantation site to improve transplantation outcomes.



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