Document Type : Original Article
Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Urology, Shariati Hosital, Tehran University of Medical Sciences, Tehran, Iran
Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Background: This study aimed to evaluate the predicting factors affecting sperm retrieval. We prospectively assessed
the relationship between sonographic and microdissection testicular sperm extraction (mTESE) findings in Klinefelter
Materials and Methods: In this prospective study, 44 azoospermic men with 47, XXY karyotypes participated in this
study. In order to evaluate the amount of blood supply in different parts of testicular tissue, a doppler ultra-sonographic
was performed. Also, for the detection of sperm in this group mTESE technique was performed.
Results: The age average of positive mTESE and negative mTESE groups was 29.4 and 33.6 years, respectively. By
comparing the testicle volume (based on the data obtained from the clinical examinations conducted by the urologist)
it was determined that there is no significant difference between mTESE positive and negative groups. Folliclestimulating
hormone (FSH) levels in men with negative mTESE (P=0.03) and testosterone levels in men with positive
mTESE significantly increased (P=0.017). The overall rate of testis vascularity was significantly higher in the positive
mTESE group than in the negative mTESE group. The clinical pregnancy rate in positive mTESE men was 9% per
cycle, 16.6% per embryos were transferred (ET), and 12.5% per cycle.
Conclusion: Totally, our observation indicated that there is not a significant relationship between sonographic and mTESE
results in KS patients. However, more investigations with bigger sample Size can be useful to validate our results.