Validity and Reliability of The Persian Version of Uterine Fibroid Symptom and Health-Related Quality of Life Questionnaire: A Psychometric Study

Document Type : Original Article


1 Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 1. Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Department of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran

3 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


Background: Women with uterine fibroids (UFs) experience many clinical manifestations that affect their quality of
life (QOL). The Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) questionnaire is an English
instrument specifically designed to assess fibroid-related symptoms and their impact on QOL. This study aims to
investigate the reliability and validity of the Persian version of the UFS-QOL questionnaire in Iranian women with UF.
Materials and Methods: In this psychometric study, women with UFs who presented to Imam Hossein Hospital
(Tehran, Iran) between August 2022 and January 2023 were enrolled in this study. A forward-backward approach
was applied to translate the UFS-QOL questionnaire into Persian. The reliability of the UFS-QOL questionnaire was
assessed by internal consistency and test-retest correlation. Confirmatory factor analysis (CFA) was used to assess
convergent validity between items and subscales of the UFS-QOL questionnaire. Pearson’s correlation coefficient was
used to assess convergence validity between subscales of the UFS-QOL and the World Health Organization Quality
of Life Brief Version 26 questionnaire (WHOQOL-BREF-26).
Results: Overall, we assessed 226 women with UFs. All subscales of the UFS-QOL questionnaire had acceptable
internal consistency (Cronbach’s alpha>0.7). Test-retest analysis indicated significant positive correlations between
two measurements of all subscales of the UFS-QOL questionnaire: symptom severity (P<0.001), concern (P<0.001),
activities (P<0.001), energy/mood (P<0.001), control (P<0.001), self-consciousness (P=0.002), and sexual function
(P<0.001). The Kaiser-Meyer-Olkin (KMO) measure value was 0.920, and the result of Bartlett’s test of sphericity
was significant (P<0.001). CFA identified six factors for the health-related QOL (HRQL) questionnaire, which explained
73.827% of the total variation. Most subscales of the UFS-QOL questionnaire correlated with domains of the
WHOQOL-BREF-26 questionnaire (P<0.05).
Conclusion: The Persian version of the UFS-QOL questionnaire is a valid and reliable instrument to evaluate UFrelated
symptoms and QOL among Iranian women.


Main Subjects

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