Anti-Thyroid Peroxidase and Risk of Recurrent Spontaneous Abortion

Document Type : Original Article


1 Endocrinology and Female Infertility Department, Reproductive Medicine Research Center, Royan Institute

2 Obstetrics and Gynecology Department, Iran University of Medical Sciences

3 Andrology Department, Royan Institute

4 Faculty Medicine, Iran University of Medical Sciences


Approximately 2-4% of all women have recurrent spontaneous abortion (RSA); however, the cause is determined in only 50% of cases. Recent studies have shown an association between thyroid autoantibodies as a sign of thyroid autoimmunity and abortion. The aim of the present study was to determine whether circulating anti-thyroid peroxidase (anti-TPO) was associated with RSA.

Materials and methods
In this observational analytic study, Sera from 58 non-pregnant women with a history of RSA and also 58 healthy, fertile subjects with at least one live birth as control (Aging from 18 to 45 years) were tested for thyroid peroxidase antibodies by means of a standard Anti-TPO ELISA kit. We used data collection forms and SPSS software for data analysis.

Of 116 women, 8 (13.8%) of the control subjects and 12 (20.7%) of the women with a history of RSA had positive results for anti-TPO. There was not any significant association between presence of anti-TPO and RSA.

We did not find any correlation between the presence of TPO antibodies and abortion in women with a history of RSA. On the basis of this study, testing for anti-TPO doesn’t seem to be useful in the evaluation of patients with a history of RSA.