Unilateral Kidney Agenesis and other Kidney Anomalies in Infertile Men with Congenital Bilateral Absence of Vas deferens: A Cross-Sectional Study

Document Type : Original Article


1 Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

2 Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran


Background: We aim to determine the prevalence of renal anomalies in patients with congenital vas deferens agenesis referred for infertility assessment.
Materials and Methods: This cross-sectional study was carried out on eligible infertile men from 2016 to 2019. Infertile men who were suspected of obstructive azoospermia were referred to the Ultrasound ward and they were examined by abdominal ultrasound for detecting the genital and kidney anomalies. An informed consent form was filled out by patients. Data was entered into SPSS software 21. Patients were divided into two groups in terms of congenital bilateral absence of vas deferens (CBAVD) or congenital unilateral absence of the vas deferens (CUAVD). Using the Chi-square test kidney anomalies between groups were compared. The P<0.05 was considered significant.
Results: The mean age of participants was 33.05 ± 6.35. The frequency of CBAVD was 66 and the frequency of left side VD and right side VD were 23 and 21, respectively. The percentage of other comorbidities was calculated. Out of 110 cases, 12 (11%) men had coexistence of vas deferens and kidney agenesis. Other studies are in agreement with our findings. Although the percentage of CBAVD and CUAVD were 9.1% and 1.8% respectively, the difference was not significant (P=0.07).
Conclusion: Considering the fact that kidney agenesis is a remarkable congenital anomaly that coexists with the majority of vas deferens agenesis cases and could not be detected by routine laboratory tests or transrectal ultrasound
examination, it should be ruled out with transabdominal ultrasound examination after detection of vas deferens agenesis.


  1. Xie C, Chen X, Liu Y, Wu Z, Ping P. Multicenter study of genetic abnormalities associated with severe oligospermia and non-obstructive azoospermia. J Int Med Res. 2018; 46(1): 107-114.
  2. Wosnitzer M, Goldstein M, Hardy MP. Review of azoospermia. Spermatogenesis. 2014; 4: e28218.
  3. Ernst LM, Ruchelli ED, Carreon CK, Huff DS. Color atlas of human fetal and neonatal histology. Switzerland: Springer; 2019.
  4. Akinsal EC, Baydilli N, Dogan ME, Ekmekcioglu O. Comorbidity of the congenital absence of the vas deferens. Andrologia. 2018; 50(4): e12994.
  5. Favorito LA, Cardinot TM, Morais AR, Sampaio FJ. Urogenital anomalies in human male fetuses. Early Hum Dev. 2004; 79(1): 41-47.
  6. Westland R, Schreuder MF, Ket JC, van Wijk JA. Unilateral renal agenesis: a systematic review on associated anomalies and renal injury. Nephrol Dial Transplant. 2013; 28(7): 1844-1855.
  7. Pichler R, Oswald J, Glodny B, Skradski V, Aigner F, Rehder P. Unilateral renal agenesis with absent ductus deferens, epididymis and seminal vesicle: incidental finding in a 22-year-old patient with maldevelopment of the mesonephric duct. Urol Int. 2011; 86(3): 365-369.
  8. Oates R, J Amos. Congenital bilateral absence of the vas deferens and cystic fibrosis. World J Urol. 1993; 11(2): 82-88.
  9. McCallum TJ, Milunsky JM, Munarriz R, Carson R, Sadeghi-Nejad H, Oates RD. Unilateral renal agenesis associated with congenital bilateral absence of the vas deferens: phenotypic findings and genetic considerations. Hum Reprod. 2001; 16(2): 282-288.
  10. Dohle GR, Veeze HJ, Overbeek SE, Van den Ouweland AM, Halley DJ, Weber RF, et al. The complex relationships between cystic fibrosis and congenital bilateral absence of the vas deferens: clinical, electrophysiological and genetic data. Hum Reprod. 1999; 14(2): 371-374.
  11. Salwan A, Abdelrahman A. Congenital absence of vas deferens and ectopic kidney. Int J Surg Case Rep. 2017; 34: 90-92.
  12. Mache C, Hubmann H. Renal agenesis, dysplasia, hypoplasia, and cystic diseases of the kidney. In: Riccabone M, Editor. Pediatric urogenital radiology. Springer, Champ; 2018; 195-203.
  13. Takizawa K, Miura K, Kaneko N, Yabuuchi T, Ishizuka K, Kanda S, et al. Renal hypoplasia can be the cause of membranous nephropathy- like lesions. Clin Exp Nephrol. 2020: 24(9): 813-820.
  14. Lane VA, Scammell S, West N, Murthi GV. Congenital absence of the vas deferens and unilateral renal agenesis: implications for patient and family. Pediatr Surg Int. 2014; 30(7): 733-736.