Association between Myometrial Thickness and Assisted Reproductive Technologies Outcomes: a prospective cohort study

Document Type : Original Article

Authors

1 Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR

2 Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

3 Department of Biostatistics, School of Nursing and Midwifery, Guilan University of Medical Sciences

4 Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR

10.22074/ijfs.2023.555447.1314

Abstract

Background: Abnormal function of the uterine muscle layer can cause common and important reproductive problems. This study aimed to evaluate the relationship between baseline myometrial thickness and assisted reproductive technologies (ART) cycles outcomes.

Materials and Methods: In total, 453 infertile women undergoing ART cycles without any obvious pathology of uterine participated in this prospective cohort study from February 2013 to May 2015. In order to measure the myometrial thickness in anterior and posterior of uterine, Trans-vaginal ultrasounds were conducted on days 2-4 of the cycle (menstrual phase) preceding ovarian stimulation and the day of human chorionic gonadotropin (hCG) injection. Three following main groups: (A) <25 mm, (B) 25-29.9 mm and (C) ≥30 mm through dividing the summation of baseline myometrial thickness in anterior and posterior (anterior-posterior diameter), preceding ovarian stimulation.

Results: The clinical pregnancy and implantation rates were significantly lower in group A as compared to groups B and C (p=0.013 and p=0.003, respectively). Although live birth rate was lower in group A than two other groups, this increase was not statistically significant (P=0.058).

Conclusion: The findings may be a way for clinicians to draw focus on providing therapeutic strategies and specific supportive care for women with the baseline myometrial thickness <25 mm in order to improve reproductive outcome of IVF/ICSI.

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International Journal of Fertility and Sterility

Articles in Press, Accepted Manuscript
Available Online from 07 May 2023

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