Document Type : Systematic Review
MD. Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran.
Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran
Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences, Tehran, Iran. Obstetric and Gynecologist, Yasuj University of Medical Sciences, Yasuj, Iran
Obstetric and Gynecologist, Yasuj University of Medical Sciences, Yasuj, Iran.
Ph.D., Department of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Science, Tehran, Iran
Ph.D., Department of Midwifery, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
Department of clinical Biochemistry, school of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Gynecology and Obstetrics, Qazvin University of Medical Sciences, Qazvin, Iran
Recurrent miscarriage (RM) is a condition defined as having three or more consecutive pregnancy losses before the 20 weeks of pregnancy. The present study was undertaken to investigate the association of interleukin-17A (IL-17A) rs2275913 polymorphism with RM. To this end, we searched the international databases (Web of Science, PubMed, Embase, and Scopus) and extracted studies investigating the association of IL-17A rs2275913 polymorphism with RM using the appropriate keywords. Collected data were analyzed by the aid of the random-effects model and STATA (version 14). A total of five studies met the eligibility criteria, and the total sample size was 998 subjects. The mean age of the cases and controls were 31.41 ± 4.16 and 30.56 ± 3.5 years, respectively. Our results disclosed a significant relationship of the IL-17A rs2275913 AA genotype (OR = 1.68; 95% CI = 1.16-2.43; I2 = 19; P = 0.294) with RM. Furthermore, there was no statistically significant correlation between IL-17A rs2275913 GG genotype (OR = 1.04; 95% CI = 0.64-1.7; I2 = 59.5; s P = 0.042) and GA genotype (OR = 0.85; 95% CI = 0.65-1.12; I2 = 19.1; P = 0.293) with RM. Our findings revealed that the IL-17A rs2275913 polymorphism is associated with RM, and the AA genotype of this polymorphism increase the possibility of being involved in RM.