Association of Interleukin-17A rs2275913 Polymorphism with Recurrent Miscarriage: A Systematic Review and Meta-Analysis Study

Document Type : Systematic Review


1 Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran

2 Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran

3 Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences, Tehran

4 Obstetric and Gynecologist, Yasuj University of Medical Sciences, Yasuj, Iran

5 Department of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Science, Tehran, Iran

6 Department of Midwifery, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran

7 Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

8 Department of Gynecology and Obstetrics, Qazvin University of Medical Sciences, Qazvin, Iran


Recurrent miscarriage (RM) is a condition defined as having three or more consecutive pregnancy losses before the
20 weeks of pregnancy. The present study was undertaken to investigate association of Interleukin-17A (IL-17A)
rs2275913 polymorphism with RM. To this end, we searched the international databases (Web of Science, PubMed,
Embase, and Scopus) and extracted studies investigating the association of IL-17A rs2275913 polymorphism with
RM using the appropriate keywords. The collected data were analyzed with the random-effects model and STATA
(version 14). A total of five studies met the eligibility criteria, and total sample size was 998 subjects. Mean age
of the cases and controls were 31.41 ± 4.16 and 30.56 ± 3.5 years, respectively. Our results disclosed a significant
relationship of the IL-17A rs2275913 AA genotype [odds ratio (OR)=1.68; 95% confidence interval (CI)=1.16-
2.43; I2=19; P=0.294) with RM. There was no statistically significant correlation between IL-17A rs2275913 GG
genotype (OR=1.04; 95% CI=0.64-1.7; I2=59.5; P=0.042) and GA genotype (OR=0.85; 95% CI=0.65-1.12; I2=19.1;
P=0.293) with RM. Our findings revealed that the IL-17A rs2275913 polymorphism is associated with RM, and the
AA genotype of this polymorphism increased possibility of being involved in RM.


Main Subjects


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