Association of Interleukin-17A rs2275913 Polymorphism with Recurrent Miscarriage: A Systematic Review and Meta-Analysis Study

Document Type : Systematic Review


1 MD. Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran.

2 Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran

3 Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences, Tehran, Iran. Obstetric and Gynecologist, Yasuj University of Medical Sciences, Yasuj, Iran

4 Obstetric and Gynecologist, Yasuj University of Medical Sciences, Yasuj, Iran.

5 Ph.D., Department of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Science, Tehran, Iran

6 Ph.D., Department of Midwifery, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran

7 Department of clinical Biochemistry, school of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

8 Department of Gynecology and Obstetrics, Qazvin University of Medical Sciences, Qazvin, Iran



Recurrent miscarriage (RM) is a condition defined as having three or more consecutive pregnancy losses before the 20 weeks of pregnancy. The present study was undertaken to investigate the association of interleukin-17A (IL-17A) rs2275913 polymorphism with RM. To this end, we searched the international databases (Web of Science, PubMed, Embase, and Scopus) and extracted studies investigating the association of IL-17A rs2275913 polymorphism with RM using the appropriate keywords. Collected data were analyzed by the aid of the random-effects model and STATA (version 14). A total of five studies met the eligibility criteria, and the total sample size was 998 subjects. The mean age of the cases and controls were 31.41 ± 4.16 and 30.56 ± 3.5 years, respectively. Our results disclosed a significant relationship of the IL-17A rs2275913 AA genotype (OR = 1.68; 95% CI = 1.16-2.43; I2 = 19; P = 0.294) with RM. Furthermore, there was no statistically significant correlation between IL-17A rs2275913 GG genotype (OR = 1.04; 95% CI = 0.64-1.7; I2 = 59.5; s P = 0.042) and GA genotype (OR = 0.85; 95% CI = 0.65-1.12; I2 = 19.1; P = 0.293) with RM. Our findings revealed that the IL-17A rs2275913 polymorphism is associated with RM, and the AA genotype of this polymorphism increase the possibility of being involved in RM.


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