Effectiveness of autologous platelet-rich plasma therapy in women with repeated implantation failure: An RCT

Document Type : Original Article


1 Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.



Background: Previous studies have examined the immune system's role in recurrent reproductive failure. It has been shown that platelet-rich plasma (PRP) therapy improves regeneration in various tissues by expressing several cytokines and growth factors.

Objective: To investigate the effect of intrauterine infusion of PRP as a non-invasive autologous growth factor on pregnancy outcomes in women with repeated implantation failure.

Materials and Methods: This randomized clinical trial was conducted to compare the pregnancy rates between two groups of women who were candidates for frozen-thawed embryo transfer with a history of two or more implantation failures. The PRP group (n = 33) was treated with hormone replacement therapy + PRP (0.5 - 1cc) infused into the uterine cavity two days before the embryo transfer. The control group (n = 33) was only treated with hormone replacement therapy. The endometrial preparation process was done similarly in both groups. The chemical, clinical, and ongoing pregnancy, also gestation, and implantation rates were compared between the two groups. Results: Our results showed that the chemical pregnancy rate was not statistically higher in the PRP group (36.4% vs. 24.2%). In addition, the clinical pregnancy, ongoing pregnancy, and implantation rates were higher in the PRP group; however, the difference between the two groups was not statistically significant.

Conclusion: According to our study, we could not show any significant improvement in ART outcome after intrauterine injection of PRP before embryo transfer.