Comparison In-vitro Fertilization Outcomes between DouStimble and Minimal Stimulation Protocols in Poor Ovarian Responders: A Randomized Clinical Trial

Document Type : Original Article

Authors

1 Preventive Gynecology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Preventive Gynecology Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

10.22074/ijfs.2023.552687.1293

Abstract

Aim: Various protocols have been approved to improve the response rate leading to successful fertilization in poor ovarian responders (PORs). The application of double ovarian stimulation (DuoStim) in the follicular and luteal phases of the same ovarian cycle has been shown as an intriguing option to achieve more oocyte retrievals in the shortest time. This study aims to compare the In-vitro Fertilization (IVF) outcomes including retrieved follicles, oocytes, MII oocytes, and embryos between minimal stimulation (MS) and DuoStim protocols in PORs.

Methods: This randomized clinical trial was performed on 42 patients diagnosed as having poor ovarian response who were candidates for IVF Patients were classified into two groups scheduling for DuoStim protocol (n = 21) and MS protocol (n = 21). The IVF outcomes including the number of retrieved follicles, oocytes, MII oocytes, and obtained embryos were compared between the two groups.

Results: The patients' characteristics including age, AMH, FSH, LH, and AFC were not different significantly between the two groups (p > 0.05). Comparison of two protocols, DuoStim protocol resulted in a significantly higher number of follicles (6.23 ± 2.93 / 1.77 ± 1.66; p < 0.001), retrieved oocytes (3.86 ± 2.57 / 1.68 ± 1.58; p = 0.002) , MII oocytes (3.36 ± 2.42 / 1.27 ± 1.27; p = 0.001) and obtained embryosthan MS (2.04 ± 1.64 / 0.77 ± 0.86; p = 0.003).

Conclusion: Our findings show that the planning of DuoStimis superior to MS protocol in terms of the number of retrieved follicles, oocytes, MII oocytes, and consequently obtained embryos.

Keywords

Main Subjects

International Journal of Fertility and Sterility

Articles in Press, Accepted Manuscript
Available Online from 09 April 2023

Files

Share

How to cite

Statistics