Document Type : Systematic Review
MD, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
PhD, Department of Radiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
PhD, Department of Radiology, Isfahan University of Medical Sciences , Isfahan, Iran.
MD, Department of Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences (AJUMS), Ahvaz, Iran.
MD, Islamic Azad University Tehran Medical Branch, Tehran, Iran.
MD, Department of Cardiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
PhD, Non-Communicable Diseases Research Center ,Ilam University of Medical Sciences, Ilam, Iran
Human Leukocyte Antigen G (HLA-G) levels are among the biomarkers suggested for pre-eclampsia (PE). This study is aimed at determining the possible relationship between low soluble HLA-G (sHLA-G) levels in maternal blood at the beginning of pregnancy and subsequent preeclampsia. We searched the international databases of Web of Science, Embase, PubMed, Cochrane, and Scopus and extracted the studies investigating the relationship between the HLA-G serum level in the first trimester of pregnancy and the onset of preeclampsia using the appropriate keywords. The collected data were analyzed using the random-effects meta-analysis model and STATA (version 14). A total of 5 studies met the eligibility criteria, and the total sample size was 668. The mean and SD age of case subjects was 31.41±4.16, while it was 30.56±3.5 years for control subjects. According to the findings, there was a significant inverse relationship between HLA-G serum level in the first trimester of pregnancy and subsequent onset of preeclampsia, SMD= -1.51 (95% CI: -2.26, -0.75, I2 = 90.8%, P = 0.000) Based on the results, low sHLA-G levels in early pregnancy has a positive relationship with subsequent pre-eclampsia, and the significant role of sHLA-G in the early stages of placentation can be inferred accordingly.