Document Type : Original Article
Authors
1
Infertility and Reproductive Health Research Center. Health Research Institute, Babol University of Medical Sciences, Babol
2
Infertility and Reproductive Health Research Center. Health Research Institute, Babol University of Medical Sciencesو, Babol, Iran
3
Health Reproductive Research Center, Sari Branch, Islamic Azad University,Sari, Iran.
4
and Reproductive Health Research Center. Health Research Institute, Babol University of Medical Sciences, Babol, Iran
5
Infertility and Reproductive Health Research Center. Health Research Institute, Babol University of Medical Sciences, , Babol, Iran .
6
Infertility and Reproductive Health Research Center. Health Research Institute, Babol University of Medical Sciences, Babol, Iran
10.22074/ijfs.2023.559352.1341
Abstract
Introduction: Bisphenol A (BPA) is known as an endocrine disruptor that has harmful effects on health. It is used in various fields a lot. In this study we tried to evaluate the amount of BPA in men referred to the infertility center.
Materials and Methods: The study population consisted of male partners of infertile couples were referred to infertility clinic in North of Iran, Mazandaran. Questionnaires include demographic characteristics, medical history, lifestyle factors, physical examinations and hormonal assay. A semen sample and a spot urine sample were taken from participants. In the initial study group of 240 men, 3 groups were excluded, then remained 122 men remained for analysis. High-performance liquid chromatography (HPLC) was applied to measure the amount of BPA in the urine.
Result: BPA was not detected in about half of the samples (53.3%). Multiple linear regression analysis showed that no significant relationship was between the urine concentrations of BPA, semen parameters and male reproductive hormones. However, in a comparison with semen parameters in people with detectable urine BPA versus not detectable one, an inverse association was noticed with sperm concentration, while for other parameters, differences were not significant. Smoking had no effect on sperm parameters, but BMI ≥25 reduced the percentage of normal sperm parameters.
Conclusion: In most participants, urinary Bisphenol A was not detected. Probably in this study low environmental exposure to BPA is the cause of lower urine Bisphenol A concentrations compared to other industrially developed countries. So, no relationship was observed between BPA level and male infertility.
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