Serum Human Chorionic Gonadotropin (hCG) and Body Mass Index (BMI) Predicts In Vitro Fertilization (IVF) Oocyte Maturation Rate: A Cross-Sectional Study

Document Type : Original Article

Authors

1 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia

2 Department of Obstetrics & Gynecology, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia

3 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia

10.22074/ijfs.2023.555467.1315

Abstract

Background: In vitro fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin (hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aims to investigate about the relationship between 12 hours post-injection hCG level and oocyte maturation rate.

Method: A cross-sectional study on IVF participants was done at a tertiary hospital in Indonesia from January 2020 to December 2021. Subjects were injected with 250 µg of r-hCG subcutaneously. Twelve hours post-injection serum hCG level and oocyte maturation rate data were retrieved and analyzed accordingly.

Result: Twenty-eight subjects were recruited into the study. Higher 12 hours post-injection serum hCG was related to oocyte maturation rate (p = 0.046). The cut-off point of 12 hours post-injection serum hCG to predict better oocyte maturation rate was 90.15 mIU/mL (sensitivity 68.2%, specificity 83.3%). Oocyte maturation rate may be predicted using BMI and 12 hours post-injection serum hCG.

Conclusion: Higher 12 hours post-injection serum hCG was associated with a higher oocyte maturation rate in IVF subjects.

Keywords

International Journal of Fertility and Sterility

Articles in Press, Accepted Manuscript
Available Online from 09 January 2023

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