Document Type : Review Article
Authors
1
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2
Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4
Department of Animal Physiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
5
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
6
Department of Obstetrics and Gynecology, Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
7
Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
10.22074/ijfs.2022.559132.1339
Abstract
Recurrent pregnancy loss (RPL) or recurrent miscarriage is the failure of pregnancy before 20–24 week that influences around 2%-5% of couples. Several genetic, immunological, environmental, and physical factors may influence RPL. Although various traditional methods have been used for post-implantation failures, identifying the mechanisms underlying RPL may improve an effective treatment. Recent evidence suggested that gene expression alterations presented essential roles in the occurrence of RPL. It has been found that long non-coding RNAs (lncRNAs) play functional roles in pregnancy pathologies, such as recurrent miscarriage. LncRNAs can function as dynamic scaffolds, modulate chromatin function, guide, and bind to miRNAs or transcription factors. LncRNAs by targeting various miRNAs and mRNAs play essential roles in the progression or suppression of RPL. Therefore, targeting lncRNAs and their downstream targets might be a suitable strategy for the diagnosis and treatment of RPL. In this review, we summarized emerging roles of several lncRNAs in the stimulation or suppression of RPL.
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