Leptin, Ghrelin, Adiponectin, Homocysteine and Insulin Resistance Related to Polycystic Ovary Syndrome

Document Type : Review Article


1 Obstetrics and Gynecology Department, Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University (MC), Tehran, Iran

2 Obstetrics and Gynecology Department, Shahid Beheshti University (MC), Tehran, Iran


The relationship between leptin, adiponectin, ghrelin, homocysteine, insulin resistance and other biochemical factors in women with polycystic ovary syndrome (PCOS) is controversial. We review how the expanded role of these factors in reproduction might impact our understanding of PCOS. For purposes of our review, we accessed the PUBMED database during the past 10 years. Our review confirms that these factors can have etiopathogenetic importance in some enigmatic reproductive disturbances such as PCOS. Moreover understanding the role of these biochemical factors might be useful for new treatments in PCOS.