Document Type : Original Article
Authors
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Abstract
Keywords
Infertility is an unpleasant, unexpected experience
for individuals. According to a populationbased
study in Iran, the overall prevalence of lifetime
primary infertility among couples is 17.3% (
To the best of our knowledge, no studies have examined the utility of Snyder’s theory of hope in patients who suffer from infertility. This study aimed to investigate the levels of hope as conceptualized by Snyder in infertile couples who undergo infertility treatment. Specifically, we sought to determine whether hope would be significantly positively or negatively related to major psychological symptoms commonly experienced by infertile patients (i.e., anxiety, stress, and depression).
We conducted this cross-sectional study on infertile couples who referred to Royan Institute, a referral infertility clinic in Tehran, Iran between 2013 and 2014. The study sample consisted of three groups of infertile couples-candidates for oocyte donation (n=60), candidates for embryo donation (n=60), and normal infertile (n=60). The inclusion criteria were aged 18 years or older, a history of infertility, and ability to read and write in Persian.
The Ethical Committee of Royan Institute approved
the study. Aims of the study and the confidentiality
of the data were clearly explained for all
participants. We reassured all eligible individuals
that acceptance or refusal to participate in the research
had no influence on their treatment procedures.
Voluntary completion of the questionnaire
was considered as written informed consent. Participants
completed three questionnaires. First, the
demographic questionnaire included age (years),
sex (male or female), educational levels (under
diploma, diploma and academic), duration of marriage
(years), and duration of treatment (months).
Second, participants completed the Adult Trait
Hope Scale published in 1991 by Snyder et al. (
We used the SPSS statistical software package (SPSS Inc, Chicago, IL, USA), version 22.0 for statistical analyses. Continues variables were expressed as mean ± SD and categorical variables as number (percentage). Normality of the variables was verified by the Kolmogorov-Smirnov test. The relationship between individual independent variables (demographic, and duration of treatment and marriage) and dependent variables (hope, agency, pathway, anxiety, depression, and stress) were assessed with Pearson correlation coefficient and we conducted the paired t test (between wives and husbands), ANOVA (between groups of infertile in hope subscales), and chi-square test (between groups of infertile in depression, anxiety and stress). Moreover, the mutual effects of demographic characteristics, hope, and groups studied were evaluated using ANCOVA. P<0.05 was considered statistically significant.
During the study period, 180 infertile couples participated. The mean age was 32.94 ± 4.74 years in men and 29.39 ± 5.09 years in women. Approximately 72 (40%) men and 60 (33.3%) women had academic educations. The mean duration of marriage was 6.07 ± 4.13 years in the couples. The mean duration of treatment was 25.73 ± 25.13 months. The demographic and fertility characteristics of the participants are given in Table 1.
As seen in Table 2, husbands had a significantly higher mean score for hope compared to wives in the normal infertile group (P=0.046). There was no significant difference in the mean score for hope in male and female patients between groups. There was no significant difference in the mean score for agency between wives and husbands in each group. The mean score for agency did not significantly differ in male and female patients between groups. In the normal infertile group, the husbands had a significantly higher mean score for pathway (P=0.032). There was no significant difference observed in the mean score for pathway in male and female patients between groups.
Demographic and general characteristics of the infertile couples (n=180)
Oocyte donation[mean ± SD or n (%)] | Embryo donation[mean ± SD or n (%)] | Normal infertile[mean ± SD or n (%)] | P value* | |||
---|---|---|---|---|---|---|
Age (Y) | Male | 33.05 ± 5.40 | 32.77 ± 4.51 | 33.02 ± 4.42 | 0.912 | |
Female | 30.10 ± 5.41 | 29.05 ± 5.09 | 29.02 ± 4.77 | 0.544 | ||
P value** | <0.000 | <0.000 | <0.000 | |||
Education | Male | <0.000 | ||||
Female | 0.006 | |||||
Under diploma | Male | 8 (13.3) | 34 (56.7) | 7 (11.7) | ||
Female | 12 (20) | 26 (43.3) | 12 (20) | |||
Diploma | Male | 26 (43.3) | 13 (21.7) | 20 (33.3) | ||
Female | 22 (36.7) | 23 (38.3) | 25 (41.7) | |||
Academic | Male | 26 (43.3) | 13 (21.7) | 33 (55) | ||
Female | 26 (43.3) | 11 (18.3) | 23 (38.3) | |||
P value** | 0.437 | 0.180 | 0.019 | |||
Marital duration (Y) | 5.37 (3.94) | 6.69 (4.27) | 6.15 (4.09) | 0.003 | ||
Treatment time (Months) | 25.52 (20) | 28.97 (31.10) | 22.72 (22.73) | 0.272 | ||
*; Test for several independent groups and **; Paired test.
Hope and its subscales in study couples and groups
Oocyte donation(mean ± SD) | Embryo donation(mean ± SD) | Normal infertile(mean ± SD) | P value* | ||
---|---|---|---|---|---|
Hope | Male | 52.38 ± 6.52 | 51.82 ± 6.86 | 53.93 ± 6.36 | 0.148 |
Female | 51.78 ± 7.17 | 50.72 ± 6.00 | 51.17 ± 7.17 | 0.735 | |
P value** | 0.614 | 0.440 | 0.046 | ||
Agency | Male | 26.05 ± 3.71 | 26 ± 2.86 | 26.69 ± 3.91 | 0.335 |
Female | 25.85 ± 3.52 | 25.62 ± 3.73 | 25.43 ± 4.37 | 0.911 | |
P value** | 0.470 | 0.902 | 0.126 | ||
Pathway | Male | 26.33 ± 3.55 | 25.82 ± 3.87 | 27.28 ± 3.44 | 0.090 |
Female | 26.17 | 24.87 ± 3.47 | 25.73 ± 3.75 | 0.210 | |
P value** | 0.735 | 0.318 | 0.032 | ||
*; Test for several independent groups and **; Paired test.
As shown in Table 3, the distribution of depression (normal, slight, medium, severe, and very severe) significantly differed in male subjects among all groups (P=0.01). The frequency of anxiety (normal, slight, medium, severe, and very severe) significantly differed in female subjects (P=0.028). The normal infertile group had a significantly different distribution for anxiety between wives and husbands (P=0.006). The frequency of stress (normal, slight, medium, severe, and very severe) significantly differed in male subjects (P=0.048). In the embryo donation group, stress significantly differed between wives and husbands (P=0.002). In the normal infertile group, stress also significantly differed between wives and husbands (P=0.05).
Depression, Anxiety, and Stress Scale (DASS) and its subscales in studied couples and groups
Oocyte donation n (%) | Embryo donationn (%) | Normal infertilen (%) | P value* | ||
---|---|---|---|---|---|
Depression | Male | 0.010 | |||
Female | 0.716 | ||||
Normal | Male | 37 (61.7) | 27 (45) | 38 (63.3) | |
Female | 34 (56.7) | 26 (43.3) | 31 (51.7) | ||
Slight | Male | 2 (3.3) | 11 (18.3) | 11 (18.3) | |
Female | 7 (11.7) | 15 (25) | 9 (15) | ||
Medium | Male | 11 (18.3) | 17 (28.3) | 5 (8.3) | |
Female | 12 (20) | 14 (23.3) | 13 (21.7) | ||
Severe | Male | 7 (11.7) | 5 (8.3) | 3 (5) | |
Female | 4 (6.7) | 2 (3.3) | 4 (6.7) | ||
Very severe | Male | 3 (5) | 0 (0) | 3 (5) | |
Female | 3 (5) | 3 (5) | 3 (5) | ||
P value** | 0.914 | 0.797 | 0.091 | ||
Anxiety | Male | 0.231 | |||
Female | 0.028 | ||||
Normal | Male | 23 (36.3) | 25 (41.7) | 31 (51.7) | |
Female | 24 (40) | 26 (43.3) | 20 (33.3) | ||
Slight | Male | 3 (5) | 4 (6.7) | 7 (11.7) | |
Female | 7 (11.7) | 8 (13.3) | 2 (3.3) | ||
Medium | Male | 13 (21.7) | 17 (28.3) | 13 (21.7) | |
Female | 15 (25) | 11 (18.3) | 17 (28.3) | ||
Severe | Male | 9 (15) | 10 (16.7) | 5 (8.3) | |
Female | 2 (3.3) | 3 (5) | 12 (20) | ||
Very severe | Male | 0 (0) | 0 (0) | 0 (0) | |
Female | 0 (0) | 0 (0) | 0 (0) | ||
P value** | 1.000 | 0.938 | 0.006 | ||
Stress | Male | 0.048 | |||
Female | 0.831 | ||||
Normal | Male | 31 (51.7) | 48 (80) | 40 (66.7) | |
Female | 30 (50) | 29 (48.3) | 31 (51.7) | ||
Slight | Male | 8 (13.3) | 3 (5) | 8 (13.3) | |
Female | 9 (15) | 13 (21.7) | 6 (10) | ||
Medium | Male | 11 (18.3) | 8 (13.3) | 5 (8.3) | |
Female | 10 (16.7) | 10 (16.7) | 13 (21.7) | ||
Severe | Male | 7 (11.7) | 1 (1.7) | 5 (8.3) | |
Female | 7 (11.7) | 4 (6.7) | 5 (8.3) | ||
Very severe | Male | 3 (5) | 0 (0) | 2 (3.3) | |
Female | 4 (6.7) | 4 (6.7) | 5 (8.3) | ||
P value** | 0.860 | 0.002 | 0.050 | ||
*; Test for several independent groups and **; Paired test.
Correlation between Depression, Anxiety, and Stress Scale (DASS) subscales and hope
Depression | Anxiety | Stress | ||||
---|---|---|---|---|---|---|
r | P value | r | P value | r | P value | |
Agency | -0.319* | <0.000 | -0.252* | <0.000 | -0.272* | <0.000 |
Pathway | -0.187* | <0.000 | -0.203* | <0.000 | -0.155* | <0.000 |
Hope | -0.276* | <0.000 | -0.249* | <0.000 | -0.228* | <0.000 |
*; P<0.05 and r; Pearson correlation coefficient.
ANCOVA results regarding the differences among the studied groups
Variable | Source | Sum of squares | DF | Mean square | F |
---|---|---|---|---|---|
Hope | Sex | 73.167 | 1 | 73.167 | 1.702 |
Age | 105.917 | 1 | 105.917 | 2.464 | |
Education | 14.444 | 1 | 14.444 | 0.336 | |
Marital duration | 14.969 | 1 | 14.969 | 0.348 | |
Treatment time | 152.952 | 1 | 152.952 | 3.558 | |
Group | 47.850 | 2 | 23.925 | 0.556 | |
*; P<0.05, DF; Degree of freedom, and F; F value.
Additionally, bivariate correlations were conducted among the subscales of the DASS and Adult Trait Hope Scale. Agency negatively and significantly correlated with depression, anxiety, and stress (P<0.001). Pathway and hope showed negative, significant correlations with depression, anxiety, and stress (P<0.001,
To the best of our knowledge, this was the first study that measured two components of the Adult Trait Hope Scale, agency and pathway, in Iranian infertile patients undergoing assisted reproduction treatment according to Snyder’s theory. This was the first study that included both infertile men and women (couples). We classified the study subjects into three groups, oocyte donation, embryo donation, and normal infertile, because the main hypothesis was that a difference existed in hope subscales among these groups and between wives and husbands. Mainly, we hypothesized that those who undergo donation (either embryo or oocyte) could show different hope and other psychological properties compared to other infertile participants. However, many studies have investigated hope in the context of chronic diseases, such as cancer (
Our study also confirmed the findings that husbands had more hope than wives in the normal infertile group. Further investigation into the two components of hope indicated in the normal infertile group a significantly higher mean score of pathway in husbands. The results of this investigation supported findings extracted from other studies that showed strong inverse relations between hope and psychological symptoms in patients who suffer from chronic diseases. Berendes et al. found an association between higher levels of hope and lower levels of depression among cancer patients (
Our study had several limitations. First, an inherent limitation of this study might be its generalizability. We relied on patients who presented to only one center, a referral clinic for infertility treatment in Iran where patients throughout the country come to this center. Second, the cross-sectional nature of the study only allowed for correlations, but not conclusions on causality.
Our study was the first study to examine Snyder’s construct of hope in a sample of infertile couples. The results suggest that hope may be important in reducing psychological symptoms and psychological adjustment in those with infertility problems who follow medical recommendations more efficiently through better behavioral patterns, which would accelerate recovery. We suggest that psychological counseling sessions (hope therapy) be offered during reproduction cycles.