Effect of CoQ10 Supplement on Spermogram Parameters and Sexual Function of Infertile Men Referred to The Infertility Center of Fatemieh Hospital, Hamadan, Iran, 2019: A Randomized Controlled Trial Study

Document Type : Original Article


1 Mother and Child Care Research Center, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran

2 Endometrium and Endometriosis Research Center, Medicine School, Hamadan University of Medical Sciences, Hamadan, Iran

3 Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

4 Department of Midwifery, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran


Background: The aim of this study was to investigate the effects of the antioxidant supplement of CoQ10 and placebo in the male infertility treatment.
Materials and Methods: The randomized controlled trial study was designed as a clinical trial. Samples in each group consisted of 30 members. The first group received 1 daily dose of 100 mg coenzyme Q10 capsules and the second group received a placebo treatment. Treatment in both groups lasted 12 weeks. Before and after the intervention of semen analysis, hormonal measurement of testosterone, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid stimulating hormone (TSH) were done. Sexual function was assessed before and after the intervention by using the International Index of Erectile Dysfunction questionnare.
Results: The mean age of participants was 34.07 (5.26) years in the CoQ10 group and 34.83 (6.22) in the placebo one. Normal volume of semen (P=0.10), viscosity (P=0.55), sperm count (P=0.28), and sperm motility (P=0.33) in the CoQ10 group increased without statistically significant differences. But the normal sperm morphology increased with statistically significant differences in the CoQ10 group (P=0.01). There was an increase in normal FSH levels and testosterone levels in the CoQ10 group compared with the placebo patients, but these differences were not statistically significant (respectively P=0.58, P=0.61). The results also revealed that the scores of erectile function (P=0.95), orgasm (P=0.86), satisfaction with sexual intercourse (P=0.61), overall satisfaction (P=0.69) and the score of the International Index of Erectile Function (IIEF, P=0.82) were greater after the intervention in the CoQ10 group than in the placebo group although the difference was not statistically significant.
Conclusion: The use of CoQ10 supplement can improve sperm morphology; however, in other sperm parameters and also in some hormones increased after the intervention, this was not statistically significant and therefore the result is not conclusive (registration number: IRCT20120215009014N322).


1. Ben Rafael Z. Should we still offer elective freezing of all embryos in all IVF cycles? Hum Reprod. 2020; 35(10): 2179-2184.
2. Mittal PK, Little B, Harri PA, Miller FH, Alexander LF, Kalb B, et al. Role of imaging in the evaluation of male infertility. Radiographics. 2017; 37(3): 837-854.
3. Babakhanzadeh E, Nazari M, Ghasemifar S, Khodadadian A. Some of the factors involved in male infertility: a prospective review. Int J Gen Med. 2020; 13: 29-41.
4. Alahmar A, Dutta S, Sengupta P. Thyroid hormones in male reproduction and infertility. Asian Pac J Reprod. 2019; 8(5): 203-210.
5. Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, et al. The impact of drugs on male fertility: a review. Andrology. 2017; 5(4): 640-663.
6. Adewoyin M, Ibrahim M, Roszaman R, Isa MLM, Alewi NAM, Rafa AAA, et al. Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress. Diseases. 2017; 5(1): 9.
7. Rodick TC, Seibels DR, Babu JR, Huggins KW, Ren G, Mathews ST. Potential role of coenzyme Q 10 in health and disease conditions. Nutrition and Dietary Supplements. 2018; 10: 1-11.
8. Alkholy UM, Abdalmonem N, Zaki A, Elkoumi MA, Hashim MIA, Basset MAA, et al. The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes. J Pediatr (Rio J). 2019; 95(2): 224-230.
9. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. Arch Iran Med. 2016; 19(8): 588-596.
10. Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: a double blind randomized clinical trial. Nutr Neurosci. 2016; 19(3): 138-143.
11. Salvio G, Cutini M, Ciarloni A, Giovannini L, Perrone M, Balercia G. Coenzyme Q10 and male Infertility: a systematic review. Antioxidants (Basel). 2021; 10(6): 874.
12. Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S, et al. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril. 2009; 91(5): 1785-1792.
13. Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. Antioxidant supplements and semen parameters: an evidence based review. Int J Reprod Biomed. 2016; 14(12): 729-736.
14. Bundhun PK, Janoo G, Bhurtu A, Teeluck AR, Soogund MZS, Pursun M, et al. Tobacco smoking and semen quality in infertile males: a systematic review and meta-analysis. BMC Public Health. 2019; 19(1): 36.
15. Fakhri A, Morshedi H, Soleymanian A. Psychometric properties of Iranian version of male sexual function index. Jundishapur Sci Med J. 2014; 12(6): 655-663.
16. Dutta S, Majzoub A, Agarwal A. Oxidative stress and sperm function: a systematic review on evaluation and management. Arab J Urol. 2019; 17(2): 87-97.
17. Bassiri F, Nasr-Esfahani MH, Forozanfar M, Tavalaee M. Relationship between sperm parameters with sperm function tests in infertile men with at least one failed intracytoplasmic sperm injection cycle. Int J Fertil Steril. 2020; 13(4): 324-329.
18. Thakur AS, Littarru GP, Funahashi I, Painkara US, Dange NS, Chauhan P. Effect of ubiquinol therapy on sperm parameters and serum testosterone levels in oligoasthenozoospermic infertile men. J Clin Diagn Res. 2015; 9(9): BC01-BC03.
19. Nadjarzadeh A, Shidfar F, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, et al. Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia. 2014; 46(2): 177-183.
20. Safarinejad MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol. 2009; 182(1): 237-248.
21. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. J Urol. 2012; 188(2): 526-531.
22. Safarinejad MR. Safety and efficacy of coenzyme Q 10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study. Int J Impot Res. 2010; 22(5): 298-309.
23. Cao L, Leers-Sucheta S, Azhar S. Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells. J Steroid Biochem Mol Biol. 2004; 88(1): 61-67.
24. Ghanbarzadeh S, Garjani A, Ziaee M, Khorrami A. Effects of L-carnitine and coenzyme q10 on impaired spermatogenesis caused by isoproterenol in male rats. Drug Res (Stuttg). 2014; 64(09): 449-453.
25. Demyashkin GA. Inhibin B in seminiferous tubules of human testes in normal spermatogenesis and in idiopathic infertility. Syst Biol Reprod Med. 2019; 65(1): 20-28.
26. Banihani SA. Effect of coenzyme q10 supplementation on testosterone. Biomolecules. 2018; 8(4): 172.