Relation of Anxiety and Doppler flow of uterine artery in pregnant women with Down syndrome risk

Document Type : Original Article


1 tums

2 royan

3 vrhrc-tums

4 thomass jefferson

5 zums

6 mums

7 tehran


Objective: This study compared the relation of anxiety and uterine artery Doppler flow indices in pregnant women with the high and low-risk of Down syndrome.
Materials and Methods: This prospective cohort study was conducted among pregnant women in the second trimester that were grouped into high and low-risk after receiving the results of prenatal aneuploidy screening test. The high-risk group underwent amniocentesis and was classified to positive or negative results. Anxiety were initially assessed using the Spielberger State-Anxiety Inventory (STAI) and uterine artery blood flow indices (immediately before amniocentesis in high- risk group) and after two weeks follow up (by receiving the karyotype results in high risk group) in groups.
Results: Totally 176 low-risk and 199 high-risk women based on the aneuploidy screening test were recruited. In the high-risk group with Down syndrome; in 176 cases; a Negative result in 23 cases; A positive result was reported. The mean state (p=0.003) and trait (p=0.033) of Anxiety Inventory scores were significantly different in two groups of high and low risk.
Baseline uterine artery indices were no significant difference in the two groups. UA indices in high-risk group had a significant difference between baseline and follow-up (in both positive-amniocentesis and negative amniocentesis sub-groups). During the follow-up period, there was a weak and significant correlation in the uterine RI and STAI scores (p = 0.008, r = 0.137).
Conclusions: All pregnant women experienced high level anxiety, especially in high-risk group that may reduce after confirmation of prenatal aneuploidy screening test and also affects the Doppler indices.
For all pregnant women; Stress management and emotional support training is recommended before and during pregnancy.