Document Type : Short Communication
SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH, CHENNAI
Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai
Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research
Department of Obstetrics & Gynaecology, Sri Ramachandra Institute of Higher Education and Research
Central Research Facility, Sri Ramachandra Institute of Higher Education and Research
DEPARTMENT OF PERIODONTICS, FACULTY OF DENTAL SCIENCES, SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH
Periodontal disease is an inflammatory process which is caused by pathogenic microbiota present in the oral biofilm that trigger innate, inflammatory and adaptive immune responses. The most common endocrine disorder affecting women of the reproductive age is Polycystic ovary syndrome (PCOS). Oxidative stress, which occurs due to an imbalance between the production of ROS and the antioxidant defense system has been suggested to have a role in the etiopathogenesis of PCOS. As proteins are a major target of free radicals, Advanced Oxidative Protein Products (AOPP) are an important biomarker of OS. This study aims to evaluate the levels of AOPP in patients with periodontitis and polycystic ovary syndrome.
OBJECTIVE: To establish the role of Chronic Periodontitis in Polycystic ovary syndrome(PCOS)
MATERIALS AND METHODS :
Four groups, each consisting of 12 patients, with both PCOS and CP (PCOSCP), systemically healthy women with CP (CP), periodontally healthy women with PCOS (PCOSPH) and periodontally and systemically healthy women (PH) were included in the study. Clinical parameters such as clinical attachment loss, bleeding on probing and PISA index were noted. AOPP was evaluated in saliva and serum samples by spectrophotometric detection as proposed by Witko-Sarsat et al modified by Kalousova et al
Salivary and serum AOPP levels were found to be the highest in the PCOSCP group. Statistical significance (p <0.05) was noted between the salivary AOPP levels of the PCOSCP group and PCOS group. PISA was greatest in the PCOSCP group followed by the PCOS group, showing the impact of PCOS on gingival inflammation.
Within the limitations of the study, it clearly demonstrates the contribution of chronic periodontitis in aggravating polycystic ovary syndrome by the increased levels of advanced oxidative protein products in patients with polycystic ovary syndrome and chronic periodontitis.