TY - JOUR ID - 704386 TI - Effectiveness of Autologous Platelet-Rich Plasma Therapy in Women with Repeated Implantation Failure: A Randomized Clinical Trial JO - International Journal of Fertility and Sterility JA - IJFS LA - en SN - 2008-076X AU - Eftekhar, Maryam AU - Neghab, Nosrat AU - Khani, Parisa AD - Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Y1 - 2024 PY - 2024 VL - 18 IS - 2 SP - 162 EP - 166 KW - embryo Implantation KW - Platelet-rich plasma KW - Pregnancy Outcome DO - 10.22074/ijfs.2023.553636.1305 N2 - Background: Platelet-rich plasma (PRP) therapy has been shown to enhance tissue regeneration by expressing severalcytokines and growth factors (GFs). This study investigated the effect of intrauterine infusion of PRP as a noninvasiveautologous GF on pregnancy outcomes in women with repeated implantation failure.Materials and Methods: This randomized clinical trial was conducted to compare the pregnancy rates between twogroups of women who were candidates for the frozen-thawed embryo transfer with a history of two or more implantationfailures. The PRP group (n=33) was treated with hormone replacement therapy+0.5 cc to 1 cc PRP infusedinto the uterine cavity two days before the embryo transfer. The control group (n=33) was only treated with hormonereplacement therapy. The endometrial preparation process was done similarly in both groups. The chemical, clinical,and ongoing pregnancy, and implantation rates were compared between the two groups.Results: Our results showed that the chemical pregnancy rate was not statistically higher in the PRP group in comparisonwith the control group (36.4 vs. 24.2%). In addition, the clinical pregnancy, ongoing pregnancy, and implantationrates were higher in the PRP group than the control group; however, the difference between the two groups was notstatistically significant.Conclusion: Administration of intrauterine PRP before embryo transfer in women with repeated implantation failure(RIF) does not affect assisted reproductive technology (ART) outcomes (registration number: IRCT2016090728950N3). UR - https://www.ijfs.ir/article_704386.html L1 - https://www.ijfs.ir/article_704386_6106375dc552acbe809c4ad409ce4d68.pdf ER -