TY - JOUR ID - 46252 TI - Serum Progesterone Levels with The Use of Four Different Types of Vaginal Progesterone in Frozen-Thawed Embryo Transfer Cycles and Related Pregnancy Outcomes JO - International Journal of Fertility and Sterility JA - IJFS LA - en SN - 2008-076X AU - Shiba, Reiko AU - Kinutani, Masayuki AU - Okano, Shinichiro AU - Ikeda, Maki AU - Fukunaga, Emi AU - Harada, Yoshihisa AU - Kawano, Reo AU - Kikkawa, Yuko AD - Kinutani Women’s Clinic, 4F 8-23 Hondori, Naka-ku, Hiroshima-city, Hiroshima-Prefecture, Japan AD - Center for Integrated Medical Research, Hiroshima University Hospital, Kasumi, Minami-ku, Hiroshima, Japan Y1 - 2021 PY - 2021 VL - 15 IS - 1 SP - 34 EP - 39 KW - Embryo transfer KW - Luteal Phase KW - Pregnancy Outcome KW - Serum Progesterone KW - Vitrification DO - 10.22074/ijfs.2021.6235 N2 - Background: Luteal phase support (LPS) is essential for hormone replacement therapy (HRT) for frozen-thawedembryo transfer (FET). However, the optimal dose and serum progesterone (P4) levels required for pregnancy arecontroversial. We attempted to determine the association between pregnancy outcomes and serum P4 levels administeredvia vaginal suppository for HRT-FET cycles on embryo transfer day.Materials and Methods: This was a secondary analysis of the dataset from the EXCULL trial, which prospectivelyinvestigated pregnancy outcomes of four different P4 vaginal suppositories (Lutinus, Utrogestan, Luteum, andCrinone) for HRT-FET. It was conducted at a private fertility clinic between December 2016 to December 2017.During this trial, 235 cycles were divided into four groups based on serum P4 values (quartile [Q] 1 group: <7.8ng/mL; Q2 group: 7.8-10.8 ng/mL; Q3 group: 10.8-13.7 ng/mL; Q4 group: >13.7 ng/mL). We investigated clinicalpregnancy rate (CPR), positive fetal heart rate (FHR), live birth rate (LBR), and miscarriage rate (MR) for eachgroup. A logistic regression analysis was performed using age, body mass index (BMI), and transferred embryosas covariates.Results: Serum P4 values (ng/mL) of each drug were as follows: Lutinus, 13.3 ± 4.9; Utrogestan, 9.3 ± 3.3; Luteum,13.6 ± 4.2; and Crinone, 8.7 ± 3.2 (mean ± standard deviation, p <0.001).The percentages of Utrogestan and Crinonewere higher in the Q1 group, while the percentages of Lutinus and Luteum were higher in the Q4 group. Nonetheless,there were no statistical differences between the Q1 and Q4 groups in CPR, FHR, LBR, and MR.Conclusion: When vaginal P4 was used for FET, although serum P4 levels on transfer day differed based on the drugthat was administered, no relationship was observed between serum progesteronelevels and pregnancy outcomes (Registrationnumber: UMIN000032997). UR - https://www.ijfs.ir/article_46252.html L1 - https://www.ijfs.ir/article_46252_7d683d9500caec4385ba7718aed2c339.pdf ER -