TY - JOUR ID - 45814 TI - Are Lean and Normal Weight Patients with Polycystic Ovarian Syndrome at Risk of Preeclampsia? JO - International Journal of Fertility and Sterility JA - IJFS LA - en SN - 2008-076X AU - Aali, Bibi Shahnaz AU - Mahdi, Seyed Adel AU - Makhaee, Nouzar AU - Soboutipour, Shiva AU - Mehdizadeh, Anahita AD - Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran AD - Obstetrics and Gynecology Department, Kerman University of Medical Sciences, Kerman, Iran AD - Community Medicine Department, Kerman University of Medical Sciences, Kerman, Iran AD - Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran Y1 - 2010 PY - 2010 VL - 4 IS - 1 SP - 5 EP - 8 KW - Preeclampsia KW - Polycystic Ovary Syndrome KW - Body Mass Index DO - 10.22074/ijfs.2010.45814 N2 - Background We examined whether pregnant women with preeclampsia have an increased rate of pre-pregnancy polycystic ovary syndrome (PCOS). This study also evaluated whether the association, if any, was a result of preeclampsia and its relationship to PCOS or dependent upon concurrent obesity. Materials and methods In this study, 75 preeclampsia cases and 225 normotensive pregnant controls, matched for age and gravidity, were enrolled. A confirmation of pre-pregnancy PCOS was ascertained by recording medical history, along with a physical examination directed for signs and symptoms of PCOS, an ultrasound report of polycystic ovaries and laboratory tests which confirmed hyperandrogenism prior to pregnancy. Body mass index (BMI) was calculated for each patient. Participants were classified into two categories: lean/normal and obese according to a BMI Results Age, gravidity and parity were not significantly different between cases and controls. However, a significant difference was found in gestational age and BMI between the groups. Additionally, preeclamptic patients more frequently suffered from pre-pregnancy PCOS than controls and a significant relationship was found between preeclampsia and previous PCOS, even amongst lean/normal weight patients. Conclusion This study provides convincing evidence that a pre-pregnancy diagnosis of PCOS could predispose the patient to preeclampsia, regardless of a concomitant obesity risk factor. UR - https://www.ijfs.ir/article_45814.html L1 - https://www.ijfs.ir/article_45814_3398765bd06f538eab1e9c3a4c1a0b30.pdf ER -