TY - JOUR ID - 45728 TI - Flexible Multi-dose GnRH Antagonist versus Long GnRH Agonist Protocol in Poor Responders: A Randomized Controlled Trial JO - International Journal of Fertility and Sterility JA - IJFS LA - en SN - 2008-076X AU - Shahrokh Tehraninejad, Ensieh AU - Fazel, Azadeh AU - Samiei, Arash AU - Rashidi, Batool AU - Kiani, Kiandokht AD - Endocrinology and Female Infertility Department, Reproductive Medicine Research Center, Royan Institute, ACECR, Tehran, Iran Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Vali-e-Asr Reproductive Health Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Endocrinology and Female Infertility Department, Reproductive Medicine Research Center, Royan Institute, ACECR, Tehran, Iran Y1 - 2009 PY - 2009 VL - 2 IS - 4 SP - 165 EP - 168 KW - GnRH Agonist KW - GnRH Antagonist KW - IVF KW - Poor Ovarian Function DO - 10.22074/ijfs.2009.45728 N2 - Background To compare a flexible, multi-dose GnRH antagonist protocol with a long GnRH .agonist protocol in poor respo Materials and methods A randomized clinical trial of 70 poor responder patients (35 patients in GnRH antagonist protocol and 35 patients in long GnRH agonist protocol) was performed at Royan Institute, Tehran, Iran. Both groups were given a fixed dose of human menopausal gonadotropin HMG) for stimulation and oral contraceptive pre-treatment. Data analyzed by student’s group) .t-test or Chi square test Results Stimulation duration, total gonadotrophins consumption, mean numbers of oocytes retrieved, formed embryos, cycle cancellation rate, and clinical pregnancy rate were similar between both groups. Although the miscarriage rate was higher in the agonist protocol group, the rate of .miscarriage was not statistically significant between both gro Conclusion A flexible, multi-dose GnRH antagonist protocol appears as effective as the long GnRH agonist protocol in poor responders. More (larger) randomized controlled trials for better .statistical analysis are recommended UR - https://www.ijfs.ir/article_45728.html L1 - https://www.ijfs.ir/article_45728_255d5453cf4af58e8f40701bfafcc16e.pdf ER -