TY - JOUR ID - 45583 TI - Endometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target JO - International Journal of Fertility and Sterility JA - IJFS LA - en SN - 2008-076X AU - Barra, Fabio AU - Ferro Desideri, Lorenzo AU - Leone Roberti Maggiore, Umberto AU - Gaetano Vellone, Valerio AU - Maramai, Mattia AU - Scala, Carolina AU - Ferrero, Simone AD - Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy;Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of G AD - Department of Surgical and Diagnostic Sciences, IRCCS Ospedale Policlinico San Martino, Genoa, Italy Y1 - 2020 PY - 2020 VL - 14 IS - 1 SP - 76 EP - 77 KW - Endometriosis KW - Genetic polymorphisms KW - Tumor Necrosis Factor KW - Alpha DO - 10.22074/ijfs.2020.5876 N2 - In the recent original research published on International Journal of Fertility and Sterility the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and endometriosis in 150 Iranian patients suffered this disease. The authors notably found a lower frequency of TNF-α -863C/A allele A among the affected patients in comparison with healthy women, although this difference was not significant by adjusting multiple testing. We deem that the authors should specify, if these patients had peritoneal nodules, ovarian endometrioma/deep infiltrating endometriosis (DIE) nodules or combination of them, since it has been hypothesized that these phenotypes may represent three distinct pathogenetic entities of endometriosis. UR - https://www.ijfs.ir/article_45583.html L1 - https://www.ijfs.ir/article_45583_e3e3f4b334c4927c367489d3ce05d0f6.pdf ER -