TY - JOUR ID - 45263 TI - Association between Environmental Dioxin-Related Toxicants Exposure and Adverse Pregnancy Outcome: Systematic Review and Meta-Analysis JO - International Journal of Fertility and Sterility JA - IJFS LA - en SN - 2008-076X AU - Pan, Xinjuan AU - Liu, Xiaozhuan AU - Li, Xing AU - Niu, Nannan AU - Yin, Xinjuan AU - Li, Ning AU - Yu, Zengli AD - College of Public Health, Zhengzhou University, Zhengzhou, China;Medical College, Henan University of Science and Technology, Luoyang, China AD - College of Public Health, Zhengzhou University, Zhengzhou, China Y1 - 2015 PY - 2015 VL - 8 IS - 4 SP - 351 EP - 366 KW - Dioxin KW - Pregnancy Outcome KW - Meta KW - Analysis DO - 10.22074/ijfs.2015.4174 N2 - Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes. However, there were inconsistent results in epidemiology studies. In view of this difference, we conducted a systematic review and meta-analysis to examine this association and to assess the heterogeneity among studies. Comprehensive literature searches were performed to search for relevant articles published in English up to 15 May 2012. In total, we identified 15 studies which included 9 cohort and 6 case control studies. The Cochrane Q test and index of heterogeneity (I2) were used to evaluate heterogeneity. In either cohort studies (I2=0.89, p < 0.0001) or case control studies (I2=0.69, p=0.02), significant heterogeneity of risk estimates were observed. Subgroup analyses found no significant increased risk of adverse pregnancy outcome with air dioxin-related compounds exposure (RR=0.99, 95% CI:0.85–1.16), no significant increased risk of spontaneous abortion (SAB) with exposure to food dioxin-related compounds (RR=1.05, 95% CI:0.80–1.37), higher significant risks of low birth weight (LBW) with exposure to food dioxin-related compounds (RR=1.55, 95% CI:1.24–1.94), and higher significant risks of birth defects with maternal solid contaminants dioxin exposure (OR=1.24, 95% CI:1.19–1.29). In conclusion, more evidences are needed to confirm the association between environmental dioxin-related compounds exposure and pregnancy outcome. UR - https://www.ijfs.ir/article_45263.html L1 - https://www.ijfs.ir/article_45263_a3747e9f9f8f2a86d2e79a0a96a8bc2a.pdf ER -