TY - JOUR ID - 45228 TI - A FSH-Secreting Pituitary Macroadenoma Causing A Testosterone Deficiency Syndrome JO - International Journal of Fertility and Sterility JA - IJFS LA - en SN - 2008-076X AU - Wang, Xiong AU - Ge, Li AU - Cui, Yuanqing AU - Lang, Cuihong AU - Hao, Cuifang AD - Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China AD - Weifang Maternal and Child Health Hospital, Shandong, China Y1 - 2014 PY - 2014 VL - 8 IS - 1 SP - 99 EP - 104 KW - infertility KW - Pituitary Adenoma KW - Semen analysis DO - N2 - FSH-secreting pituitary adenomas can affect sexual and reproductive function. In this article, we have reported the case of a 32-year-old male with secondary infertility. The patient had sexual and reproductive disturbances. The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels. Based on previous hormonal results, the patient received pituitary stimulation and human chorionic gonadotropin (hCG) tests. Both follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed low response during the pituitary stimulation test. The results of the hCG test indicated that T/E2 could recover to a normal level. In addition, this patient was diagnosed with pituitary macroadenoma, which was supported by the pituitary MRI. The man’s sexual and reproductive functions recovered following surgery. The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining. The purpose of this report was to review the relative literature and discuss the influence of FSH-secreting pituitary adenomas on hormones through the hypothalamus-pituitary-testis axis. UR - https://www.ijfs.ir/article_45228.html L1 - https://www.ijfs.ir/article_45228_852c335a3c175ff462e3a997534b3ee4.pdf ER -