TY - JOUR ID - 45222 TI - Variations in T-helper 17 and Regulatory T Cells during The Menstrual Cycle in Peripheral Blood of Women with Recurrent Spontaneous Abortion JO - International Journal of Fertility and Sterility JA - IJFS LA - en SN - 2008-076X AU - Sereshki, Nasrin AU - Gharagozloo, Marjan AU - Ostadi, Vajihe AU - Ghahiri, Ataollah AU - Roghaei, Mohammad Ali AU - Mehrabian, Ferdos AU - Andalib, Alireza Andalib AU - Hassanzadeh, Akbar AU - Hosseini, Habibolla AU - Rezaei, Abbas AD - Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Obstetrics and Gynecology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran AD - School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran AD - 4Isfahan University of Medical Sciences, Isfahan, Iran Y1 - 2014 PY - 2014 VL - 8 IS - 1 SP - 59 EP - 66 KW - Regulatory T Cells KW - T Helper 17 KW - Menstrual Cycle KW - Pregnancy DO - N2 - Background: Disorders in immune system regulation may result in pregnancy abnormalities such as recurrent spontaneous abortion (RSA). This study aims to determine the ratio of regulatory T (Treg) and T helper (Th) 17 cells in unexplained RSA (URSA) women during proliferative and secretory phases of their menstrual cycles compared to healthy non-pregnant women. Materials and Methods: In this case control study, 25 women with URSA and 35 healthy, non-pregnant women were enrolled. The percentage of Th17 and Treg cells in participants peripheral blood were determined by flow cytometry. Results: The percentage of Th17 cells and their related cytokines in serum (IL-17A) were higher in the proliferative and secretory phases of the menstrual cycles of URSA women compared to the control women. However, a lower percentage of Treg cells and their related cytokines in serum, transforming growth factor (TGF) β1 and interleukin (IL)-10 were detected in the proliferative but not the secretory phase of the URSA group. The ratio of Th17/CD4+ Treg was higher in the URSA group than the control group. We observed an increased ratio of Th17/CD4+ Treg during the proliferative and secretory phases in URSA women. Conclusion: The imbalance between Th17 and Treg cells during the proliferative phase of menstrual cycles in the URSA group may be considered a cause for spontaneous abortion. UR - https://www.ijfs.ir/article_45222.html L1 - https://www.ijfs.ir/article_45222_556c7e293e4fb44fc886d9dd91369ae5.pdf ER -