Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
The Role of Toll Like Receptors in Pregnancy
147
154
EN
Elham
Amirchaghmaghi
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Seyed Abdolvahab
Taghavi
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
vahab.taghavi@gmail.com
Farnaz
Shapouri
Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center,
Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Shaghayegh
Saeidi
Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center,
Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Abbas
Rezaei
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
rezaei@mui.ac.ir
Reza
Aflatoonian
0000-0002-8570-583X
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center,
Royan Institute for Reproducti
r.aflatoonian@gmail.com
For many years, the innate immunity was of less interest than the adaptive immunity because it was perceived to have secondary importance in the functionality of the immune system. During the past decades, with the advancement of knowledge about innate immune system, interest in innate immunity has grown dramatically and thus its function has been extensively studied. Innate immunity plays fundamental roles in the initiation and induction of adaptive immune responses. It consists of several cells and receptors including natural killer (NK) cells, macrophages (MQs), dendritic cells (DCs) and pattern recognition receptors (PRRs). Two decades ago, Toll like receptors (TLRs) family was known as one of the important PRRs with unique functions especially in protection against invading pathogens. Since the female reproductive tract has access to the outside environment and has a unique interaction with different pathogens whether invading microorganisms or normal flora, allogenic sperm and semi allogenic fetus, it has an essential need for effective immune responses. It has therefore been suggested that TLRs may play important roles in the immune regulation of the female reproductive tract. In addition, it has been demonstrated that immune disturbance may be responsible for some adverse pregnancy outcomes such as preeclampsia (PE), recurrent spontaneous abortion (RSA) and intrauterine growth restriction (IUGR). Our focus in this review is to show the importance of TLRs in pregnancy with emphasis on the expression of these receptors in different tissues related to pregnancy.
Innate immunity,TLRs,Pregnancy,PRRs
https://www.ijfs.ir/article_45186.html
https://www.ijfs.ir/article_45186_e4b70a2b12dd7224c178d19d91920b87.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Hysterosalpingography Finding in Intra Uterine Adhesion (Asherman’ s Syndrome): A Pictorial Essay
155
160
EN
Firoozeh
Ahmadi
f_ahmadi@royaninstitute.org
Shiva
Siahbazi
Farnaz
Akhbari
Bita
Eslami
Ahmad
Vosough
Destruction of the endometrium due to trauma to the basal layer of endometrium may cause intra uterine adhesions, known as Asherman’s syndrome (AS). There are various types of imaging method for diagnosis of the intra uterine adhesion such as hysterosalpingography, sonohysterography, ultrasonography, and hysteroscopy which is considered as the gold standard approach. Hysterosalpingogram may suggest the presence of intrauterine adhesions, and may reveal the extent of the scar formation. Knowing different images in each technique is helpful in detection of intra uterine adhesion.
Hysterosalpingography,Adhesion,Asherman’s Syndrome,Imaging Technique
https://www.ijfs.ir/article_45187.html
https://www.ijfs.ir/article_45187_d8cab68f9579c332f63263dd744b0cbe.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Quality of Bovine Chilled or Frozen-Thawed Semen after Addition of Omega-3 Fatty Acids Supplementation to Extender
161
168
EN
Abbas
Abavisani
Division of Physiology, Department of Basic Sciences, Veterinary Faculty, Ferdowsi University of Mashhad, Mashhad, Iran;Embryonic and Stem Cell Biology and Biotechnology Research Group, Institute of Biotechnology, Ferdowsi Univers
abavisania@um.ac.ir
Javad
Arshami
Department of Animal Sciences, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
Abbas Ali
Naserian
Department of Animal Sciences, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
Mohammad Ali
Sheikholeslami Kandelousi
Department of Animal Sciences, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
Mohammad
Azizzadeh
4Department of Clinical Sciences, Faculty of Veterinary Science, Ferdowsi University of Mashhad, Mashhad, Iran
Background: This study was conducted to evaluate the potential protective effects of omega-3 poly unsaturated fatty acids (Ω-3 PUFAs) on bovine sperm quality in response to cooling and cryopreservation. Materials and Methods: In this experimental study included ejaculates from five proven fertile bulls, allocated to the control and the four experimental groups. For group 1, polyethylene glycol (PEG) as a solvent was added alone to the extender, while for groups 2, 3 and 4, different concentration of omega-3 PUFAs (1, 2.5 and 5%, respectively) in combination with PEG were added to the semen extender. Motility [using computer aided sperm analysis (CASA)], viability and morphology of bovine sperm were investigated after 24 and 48 hours in both cold liquid storage and frozen-thawed conditions. Results: Our findings showed that PEG has some detrimental effects on sperm quality. Cooling as well as cryopreservation decreased significantly most of measured variables of sperm as compared to fresh semen, whereas the treatments did not improve sperm quality. Furthermore, levels of some variables were decreased significantly during treatments (p < 0.05). Conclusion: Addition of Ω-3 PUFAs to semen extenders cannot be effectively introduced to conservation media as well as sperm membrane in order to protect spermatozoa in response to cooling and freezing. It can be suggested if Ω-3 PUFAs is supplemented to the diet of bulls in order to modify the fatty acid compositions of sperm, they might perform their preventive properties.
Bovine,Semen analysis,Omega,3 Fatty Acids,Chilling,Freezing
https://www.ijfs.ir/article_45188.html
https://www.ijfs.ir/article_45188_49f9c8a4a47de24db6c3b96f3f0f92a4.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
The Effect of Prenatal Education on Mother’s Quality of Life during First Year Postpartum among Iranian Women: A Randomized Controlled Trial
169
174
EN
Nosrat
Bahrami
Department of Midwifery, Faculty of Nursing and Midwifery, Dezful University of Medical Sciences, Dezful, Iran
bahrami.n@dums.ac.ir
Masoumeh
Simbar
Department of Reproductive Health and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
msimbar@yahoo.com
Somayeh
Bahrami
Department of Statistics, Dezful University of Medical Sciences, Dezful, Iran
Background: Antenatal educations provide information regarding pregnancy, birth, infant care and early parenthood. The purpose of this study was to determine effect of prenatal education on mother’s quality of life during first year after childbirth among Iranian women. Materials and Methods: This single-blind randomized control trial study was performed on 160 first-time pregnant women; with a singleton fetus; aged 18 to 35; without history of medical, psychological, and infertility diseases; as well as with at least eight prenatal visits during pregnancy. Participants were invited into two groups of intervention (n=80) and control (n=80). The antenatal education classes were consisted of eight sessions, and then, mother’s quality of life was evaluated during first year after childbirth. Data was analyzed using t test, chi-square, and Mann-Withney. Results: The interventional group demonstrated higher scores of quality of life domains than the control group (p < 0.05). The interventional group (at one year postpartum) demonstrated significantly higher scores for quality of life in the physical health, psychological health, and environmental health domains compared to the control group. In addition, the interventional group showed a significant increase in the mean scores for the domains of physical, psychological, and environmental health from 6-8 weeks to 1 year postpartum. Conclusion: The study showed that women receiving prenatal education had higher level of happiness and satisfaction in their overall quality of life and health, respectively (Registration Number: IRCT201101115571N2).
Prenatal,Quality of Life,Postpartum,health
https://www.ijfs.ir/article_45189.html
https://www.ijfs.ir/article_45189_294d25865071e8d307a00a52ecd7ec16.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Reproductive Outcome following Hysteroscopic Monopolar Metroplasty: An Analysis of 203 Cases
175
180
EN
Ensieh
Shahrokh Tehraninejad
Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute
for Reproductive Biomedicine, ACECR, Tehran, Iran;Department of Obstetrics and Gynecology, Tehran Universit
eshtehrani@yahoo.com
Firouzeh
Ghaffari
Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute
for Reproductive Biomedicine, ACECR, Tehran, Iran
f.ghaffari@royaninstitute.org
Nadia
Jahangiri
Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute
for Reproductive Biomedicine, ACECR, Tehran, Iran
jahangiri_n@yahoo.com
Mansoureh
Oroomiechiha
Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute
for Reproductive Biomedicine, ACECR, Tehran, Iran
Mohammad Reza
Akhoond
4Department of Epidemiology and Reproductive Health at Reproductive Epidemiology Research Center, Royan
Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Elham
Aziminekoo
Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran
Background: The aim of this study was to evaluate the reproductive outcome of women with history of infertility or recurrent miscarriage following hysteroscopic septum resection. Materials and Methods: This was a retrospective descriptive study performed on 263 patients, among whom 248 patients were infertile (79% with primary infertility and 21% with secondary infertility) and 15 patients presented with histories of recurrent miscarriage (three or more miscarriages) between 2005 and 2009. All participants underwent hysteroscopic septum resection using monopolar knife electrode. The main outcome measure was reproductive outcome after hysteroscopic metroplasty. Results: The septum was completely removed during the first hysteroscopy in 242 (92%) patients. A residual septum was seen in 21 (8%) patients who required a second sitting of surgery. Three cases were complicated by minor perforations which required no further interventions. One operation complicated with bleeding which was controlled by a Foley catheter. There were no cases of postoperative Asherman’s syndrome. Postoperatively, out of 263 patients, outcomes of 203 individuals were analyzed. According to the results, the miscarriage rate reduced significantly from 20.2 to 4.9%. Postoperative ectopic pregnancy rate and preterm labor were lower than prior to septum resection. Term deliveries increased significantly from 2.5 to 33.5%. Conclusion: Hysteroscopic septum resection is a safe and effective method for patients with history of infertility or recurrent miscarriage.
Uterine Septum,Hysteroscopic Metroplasty,infertility,Reproductive Outcome,Assisted Reproductive Techniques
https://www.ijfs.ir/article_45190.html
https://www.ijfs.ir/article_45190_20a4803a238aa7e5616eac71c196e49e.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Steroid Production and Follicular Development of Neonatal Mouse Ovary during in vitro Culture
181
186
EN
Shabnam
Abdi
Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Mojdeh
Salehnia
0000-0001-7861-2232
Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
mojdehsalehnia@gmail.com
Saman
Hosseinkhani
Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Background: The aim of this study was to investigate follicular growth and steroid production in neonatal mouse ovary during in vitro culture. Materials and Methods: In this experimental study, 7-day-old mouse whole ovaries were cultured in α-MEM (medium supplemented with 100 mIU/ml recombinant follicle stimulating hormone, 1% insulin, transferrin and selenium (ITS), 5% fetal bovine serum (FBS), 100 IU/ml penicillin and 50 μg/ml streptomycin for 7 days. The size of whole ovary was determined as mean area during culture. The survival rates of isolated preantral follicles after culture were assessed using trypan blue staining after being mechanically isolated. Histological evaluation of whole ovary was done by hematoxylin and eosin staining. 17-β estradiol, progesterone and dehydroepiandrosterone concentrations in the medium were measured during culture. Results: The mean area of ovary increased after culture (1.47 vs. 0.21 mm2). The survival rate of isolated follicles in ovary after culture was 99.2%. There was a significant decline in the percentage of primordial follicles after seven days of culture (91.8 ± 0.2% vs. 65.1 ± 1.1%), whereas the rate of preantral follicles increased significantly (4.6 ± 0.4% vs. 29.2 ± 0.5%). The levels of estradiol, progesterone and dehydroepiandrosterone also increased significantly after culture (p < 0.001). Conclusion: These results show that the growth and development of primordial follicles in contrast with hormonal production decreased during in vitro culture of neonatal mouse ovaries.
Primordial Follicles,Ovary,Organ Culture
https://www.ijfs.ir/article_45191.html
https://www.ijfs.ir/article_45191_eceb6edfa4f17c96daf88589cc4e4b65.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
New Insight from Using Spatiotemporal Image Correlation in Prenatal Screening of Fetal Conotruncal Defects
187
192
EN
Zuo-ping
Xie
Department of Diagnostic Ultrasound, Shaoxing Women and Children’s Hospital, Shaoxing, Zhejiang, China
Bo-wen
Zhao
Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University
College of Medicine, Hangzhou, China
zbwcjp@163.com
Hua
Yuan
Department of Diagnostic Ultrasound, Shaoxing Women and Children’s Hospital, Shaoxing, Zhejiang, China
Qi-qi
Hua
Department of Diagnostic Ultrasound, Shaoxing Women and Children’s Hospital, Shaoxing, Zhejiang, China
She-hong
Jin
Department of Diagnostic Ultrasound, Shaoxing Women and Children’s Hospital, Shaoxing, Zhejiang, China
Xiao-yan
Shen
Department of Diagnostic Ultrasound, Shaoxing Women and Children’s Hospital, Shaoxing, Zhejiang, China
Xin-hong
Han
Department of Diagnostic Ultrasound, Shaoxing Women and Children’s Hospital, Shaoxing, Zhejiang, China
Jia-mei
Zhou
Department of Diagnostic Ultrasound, Shaoxing Women and Children’s Hospital, Shaoxing, Zhejiang, China
Min
Fang
Department of Diagnostic Ultrasound, Shaoxing Women and Children’s Hospital, Shaoxing, Zhejiang, China
Jin-hong
Chen
Department of Diagnostic Ultrasound, Shaoxing Women and Children’s Hospital, Shaoxing, Zhejiang, China
Background: To establish the reference range of the angle between ascending aorta and main pulmonary artery of fetus in the second and third trimester using spatiotemporal image correlation (STIC), and to investigate the value of this angle in prenatal screening of conotruncal defects (CTDs). Materials and Methods: Volume images of 311 normal fetuses along with 20 fetuses with congenital heart diseases were recruited in this cross-sectional study. An offline analysis of acquired volume datasets was carried out with multiplanar mode. The angle between aorta and pulmonary artery was measured by navigating the pivot point and rotating axes and the reference range was established. The images of ascending aorta and main pulmonary artery in fetuses with congenital heart diseases were observed by rotating the axes within the normal angle reference range. Results: The angle between ascending aorta and main pulmonary artery of the normal fetus (range: 59.1˚~97.0˚, mean ± SD: 78.0˚ ± 9.7˚) was negatively correlated with gestational age (r = -0.52; p < 0.01). By rotating the normal angle range corresponding to gestational age, the fetuses with CTD could not display views of their left ventricular long axis and main pulmonary trunk correctly. Conclusion: The left ventricular long axis and main pulmonary trunk views can be displayed using STIC so that the echocardiographic protocol of the cardiovascular joint could be standardized. The reference range of the angle between ascending aorta and main pulmonary artery is clinically useful in prenatal screening of CTD and provides a reliable quantitative standard to estimate the spatial relationship of the large arteries of fetus.
Spatiotemporal Image Correlation,Ultrasonography,Fetus,Conotruncal Defects
https://www.ijfs.ir/article_45192.html
https://www.ijfs.ir/article_45192_09fbdbd99fe242f27d811a033a15004e.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Correlation between Different Patterns of Hypo-Osmotic Swelling and Sperm Functional Tests
193
198
EN
Farzaneh
Bassiri
Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for
Biotechnology, ACECR, Isfahan, Iran
farzaneh.bassiri65@gmail.com
Marziyeh
Tavalaee
Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for
Biotechnology, ACECR, Isfahan, Iran
Mohammad Hossein
Nasr Esfahani
0000-0003-1983-3435
Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for
Biotechnology, ACECR, Isfahan, Iran;Isfahan Fertility and Infertility Center, Isfahan, Iran;Department of Embryol
mh.nasr-esfahani@royaninstitute.org
Background: Sperm membrane integrity is not only important as a barrier between intra- and extra-cellular spaces, but also it can be considered as a sign of DNA integrity. Hypoosmotic swelling test reflects membrane integrity and has been used to evaluate sperm quality. Intracytoplasmic sperm injection (ICSI) in adjunct with hypo-osmotic swelling test (HOST) has been used for treatment of males with asthenozoospermia. Therefore, this study aims to evaluate correlation of different pattern of HOST with sperm parameters, protamine deficiency and apoptosis. Materials and Methods: In this case-control study, sixteen semen samples were randomly collected from infertile normozospermic men. Semen samples were divided into two portions as follows: one portion was assessed for sperm parameters according toWorld Health Organization (WHO)-2010, while the other portion, after applying HOST procedure, was used for assessment of sperm morphology, protamine deficiency and late or early apoptosis. Statistical analysis was carried out using the Statistical Package for the Social Studies (SPSS 11.5). Results: Our results showed that, the lowest odds ratio (OR) of abnormal sperm head morphology and abnormal acrosome was in d-sperm as compared to a-pattern or nonviable spermatozoa (p=0.00, p=0.01). In addition, a significant correlation was observed between d-sperm with sperm concentration and percentage of DNA damage (p=0.03 and p=0.04, respectively). A significant correlation was observed between percentage of sperm motility and DNA fragmentation (r=-0.56; p=0.01). Furthermore, significant correlations were observed between percentages of early apoptotic sperm with protamine deficiency and sperm concentration (p=0.009 and p=0.01, respectively). Conclusion: Significant correlations exist between d-pattern and sperm DNA integrity. Semen samples with low sperm concentration have low percentage of d-sperm which are mature and intact sperms.
ICSI,host,DNA fragmentation,Protamine
https://www.ijfs.ir/article_45193.html
https://www.ijfs.ir/article_45193_7be8dd17420f5619097772d00b870fa9.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
The Effect of The Cognitive Behavioral Therapy and Pharmacotherapy on Infertility Stress: A Randomized Controlled Trial
199
206
EN
Mahbobeh
Faramarzi
0000-0002-3568-7039
Fatemeh Alzahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
mahbob330@yahoo.com
Hajar
Pasha
Fatemeh Alzahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
pashahajar@yahoo.com
Seddigheh
Esmailzadeh
Fatemeh Alzahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
Farzan
Kheirkhah
Department of Psychiatry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
f.khairkhah@mubabol.ac.ir
Shima
Heidary
Department of Psychology, Payame Noor University, Tehran Branch, Iran
Zohreh
Afshar
4Library of Center, Mazandaran University of Medical Sciences, Sari, Iran
Background: Infertility has been described as creating a form of stress leading to a variety of psychological problems. Both psychotherapy and pharmacotherapy are effective treatments for infertility stress. The aim of this study was to evaluate the effectiveness of cognitive behavioral therapy along with fluoxetine for improvement infertility stress in infertile women. Materials and Methods: In a randomized controlled clinical trial, 89 infertile women with mild to moderate depression (Beck scores 10-47) were recruited into the following three groups: i. cognitive behavior therapy (CBT), ii. antidepressant therapy, and iii. control group. Twenty-nine participants in the CBT method received gradual relaxation training, restructuring, and eliminating of negative automatic thoughts and dysfunctional attitudes to infertility for 10 sessions. Thirty participants in the pharmacotherapy group took 20 mg fluoxetine daily for 90 days. Thirty individuals in control group did not receive any intervention. All participants completed fertility problem inventory (FPI) and the Beck Depression Inventory (BDI) at the beginning and end of the study. We applied Chi-square paired t test, ANOVA and Turkey’s test to analyze the data. Results: The mean of the infertility stress scores in CBT, fluoxetine, and control groups at the beginning and end of the study were as follows, respectively: 3.5 ± 0.62 vs.2.7 ± 0.62 (p < 0.05), 3.5 ± 0.53 vs.3.2 ± 4.4 (p < 0.05), and 3.4 ± 0.55 vs. 3.5 ± 0.48. In CBT group, the mean scores of social concern, sexual concern, marital concern, rejection of child-free lifestyle, and need for parenthood decreased meaningfully compared to those before starting the therapy. But in fluoxetine group, mean score of women sexual concern out of those five main problems of infertility reduced significantly. Also, fluoxetine and CBT reduced depression compared to the control group. Conclusion: CBT improved the social concerns, sexual concerns, marital concerns, rejection of child-free lifestyle, and need for parenthood more than floxitine group. Thus, CBT was not only a reliable alternative to pharmacotherapy, but also superior to fluoxetine in resolving and reducing of infertility stress (Registration Number: IRCT2012061710048N1).
infertility,Stress,Cognitive Behavior Therapy,Fluoxetine
https://www.ijfs.ir/article_45194.html
https://www.ijfs.ir/article_45194_1ae994de4c71456151626673c9a944dc.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Pregnancy Rate after First Intra Cytoplasmic Sperm Injection- In Vitro Fertilisation Cycle in Patients with Endometrioma with or without Deep Infiltrating Endometriosis
207
216
EN
Anne
Oppenheimer
Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6
University, Paris, France
Marcos
Ballester
Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6
University, Paris, France
Emmanuelle
Mathieu d’Argent
Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6
University, Paris, France
Karine
Morcel
Department of Gynecology-Obstetrics, Rennes Hospital, Paris, France
Jean-Marie
Antoine
Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6
University, Paris, France
Emile
Daraï
Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6
University, Paris, France
emile.darai@tnn.aphp.fr
Background: To evaluate the impact of the association of endometrioma with or without deep infiltrating endometriosis (DIE) after a first intra cytoplasmic sperm injection- in vitro fertilization (ICSI-IVF) cycle on pregnancy rate. Materials and Methods: In this retrospective study, women with endometrioma who underwent a first ICSI-IVF cycle from January 2007 to June 2010 were reviewed for pregnancy rate. The main outcome measure was the clinical pregnancy rate. A multiple logistic regression (MLR) was performed; including all variables that were correlated to the conception rate. Only independent factors of pregnancy rate were included in a Recursive Partitioning (RP) model. Results: The study population consisted of 104 patients (37 without DIE and 67 patients with associated DIE). Using multivariable analysis, a lower pregnancy rate was associated with the presence of DIE (OR=0.24 (95% CI: 0.085-0.7); p=0.009) and the use of ICSI (OR=0.23 (95% CI: 0.07-0.8); p=0.02). A higher pregnancy rate was associated with an anti-mullerian hormone (AMH) serum level over 1 ng/ml (OR=4.3 (95% CI: 1.1-19); p=0.049). A RP was built to predict pregnancy rate with good calibration [ROC AUC (95% CI) of 0.70 (0.65-0.75)]. Conclusion: Our data support that DIE associated with endometrioma in infertile patients has a negative impact on pregnancy rate after first ICSI-IVF cycle. Furthermore, our predictive model gives couples better information about the likelihood of conceiving.
Endometrioma,Assisted Reproductive Technology,Endometriosis,Probabilistic Model
https://www.ijfs.ir/article_45195.html
https://www.ijfs.ir/article_45195_b76f23d3c16b70f40261ef578994bb34.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Comparison of Congenital Abnormalities of Infants Conceived by Assisted Reproductive Techniques versus Infants with Natural Conception in Tehran
217
224
EN
Mansoureh
Farhangniya
Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive
Biomedicine, ACECR, Tehran, Iran;Department of Epidemiology and Statistic, Kerman University of Medical Science, Kerma
Eshagh
Dortaj Rabori
Department of Epidemiology and Statistic, Kerman University of Medical Science, Kerman, Iran
Ramin
Mozafari Kermani
Department of Child Health Research ACECR-Tehran Medical Science Branch, Tehran, Iran
Ali Akbar
Haghdoost
4Modeling Research Center, Kerman University of Medical Science, Kerman, Iran
Abbas
Bahrampour
Department of Epidemiology and Statistic, Kerman University of Medical Science, Kerman, Iran
Pezhman
Bagheri
5Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
Paul
A. L. Lancaster
6Menzies Centre for Health Policy, School of Public Health, University of Sydney,Sydney, NSW Australia
Mahnaz
Ashrafi
7Department of Endocrinology and Female Infertility, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
ashrafim@royaninstitute.org
Ahmad
Vosough Taqi Dizaj
8Department of Reproductive Imaging at Reproductive Biomedicine Research Center, Royan Institute for Reproductive
Biomedicine, ACECR, Tehran, Iran
Hamid
Gourabi
Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive
Biomedicine, ACECR, Tehran, Iran
Abolhassan
Shahzadeh Fazeli
Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive
Biomedicine, ACECR, Tehran, Iran
fazeli@ibrc.ir
Background: In many countries, 1 to 3% of newborn infants are conceived by assisted reproductive techniques (ART). Despite the success of ART, there is concern about the risk of congenital malformations among these infants. We report our experience to determine whether use of ART is associated with an increase in major congenital malformations or adverse pregnancy outcomes. Materials and Methods: Historical cohort study of major congenital malformations (MCM) was performed in 978 births from January 2008 to December 2010. The data for this analysis were derived from a Tehran’s ART linked data file by simple sampling method. In our study, the risk of congenital malformations was compared in 326 ART infants and 652 naturally conceived (NC) infants. We also performed multiple logistic regression analyses to calculate the odds ratio (OR) and 95% confidence intervals (CI) for the independent association of ART on each outcome. Results: We found 56 infants with major congenital malformations, these included 29 NC infants (4.4%) and 27 ART infants (8.3%). In comparison with NC infants, ART infants had a significant 1.94-fold increased risk of MCM.After adjustment for maternal age, infant’s sex stillbirth, abortion and type of delivery, we found a relatively small difference in risk (OR=2.04). In this study the majority (94.3%) of all infants were normal but 5.7% of infants had at least one MCM. The prevalence rate for the intracytoplasmic sperm injection (ICSI) was 6.5% for the In vitro fertilisation (IVF) group was 15.9% or 2.73-fold higher than ICSI group (P=0.018). Also we ignore the possible role of genotype and other unknown factors in causing more malformations in ART infants. Conclusion: Other studies have shown a slightly increased risk of major congenital malformations in pregnancies resulting from ART. Likewise, this study reports a greater risk of MCMs in ART infants than in naturally conceived infants. We also found evidence of a difference in risk of MCMs between IVF and ICSI. Musculoskeletal and urogenital malformations were the most reported MCMs in ART infants according to organs and systems classification.
infants,Assisted reproductive technique,congenital malformations,Anomaly,Conception,Fertilization
https://www.ijfs.ir/article_45196.html
https://www.ijfs.ir/article_45196_6ec9c4fe3ade0677b9e795cb86521a1e.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Study on The Reproductive Organs and Fertility of The Male Mice following Administration of Metronidazole
225
238
EN
Mrinalini
Kumari
Poonam
Singh
poonom@gmail.com
Background: Metronidazole (MTZ) is commonly used as an antibacterial and antiprotozoal drug. Various doses of MTZ have been reported to inhibit spermatogenic activity and sperm indices. Materials and Methods: In this experimental study, dose-dependent effects of MTZ on the structural and functional integrity of the testis and accessory reproductive organs have been investigated. Adult male mice of Swiss strain were administered orally with MTZ at the doses of 250 mg/kgBW/day and 500 mg/kgBW/day for 28 consecutive days to study the changes in the testis, epididymis, seminal vesicle, sperm indices and fertility. Reversal effects of the drug were also studied on the same mice, 42 days after cessation of the treatment. Results: Therapeutic dose of MTZ (250 mg/kgBW/day) neither altered the weights of the testis, epididymis and seminal vesicle nor their histoarchitecture and sperm indices. The drug at the high dose (500 mg/kg BW/day) caused significant reductions in the weights of the testis and epididymis. Histoarchitecture of the testis and epididymis at the high dose revealed marked regressive changes while that of seminal vesicle remained unaffected. Significant reductions were noticed in the motility, viability and count of epididymal spermatozoa while the concentrations of epididymal sialic acid and seminal vesicular fructose remained unaltered after the treatment. No significant changes were noticed in the mating ability as well as in the level of serum testosterone in the treated mice. Fertility of the male mice treated with high dose of MTZ declined markedly leading to an increase in pre- and postimplantation loss while a significant decrease was noticed in the number of live blastocysts in females impregnated with such males. MTZinduced changes in the male reproductive organs and fertility were reinstated 42 days after cessation of the treatment. Conclusion: High dose of MTZ induced reversible deleterious effects on the male reproduction and fertility.
Epididymis,Metronidazole,Seminal Vesicle,Sperm,Testis
https://www.ijfs.ir/article_45197.html
https://www.ijfs.ir/article_45197_21e32d8318b0215f209e5183fe522f10.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Spontaneous Rupture of Uterus in Midtrimester Pregnancy Due to Increased Uterine Pressure with Previous Laparoscopic Myomectomy
239
242
EN
Mine
Kiseli
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ufuk, Ankara, Turkey
;Department of Obstetrics and Gynecology, Elazıg Training and Research Hospital, Elazıg, Turkey
minekiseli@gmail.com
Hakan
Artas
Department of Radiology, Elazıg Training and Research Hospital, Elazıg, Turkey
Figen
Armagan
Department of Obstetrics and Gynecology, Elazıg Training and Research Hospital, Elazıg, Turkey
Zeynep
Dogan
Department of Obstetrics and Gynecology, Elazıg Training and Research Hospital, Elazıg, Turkey
Uterine rupture is a life threatening condition for both the mother and her fetus. It may be seen in the second trimester usually after induction for pregnancy termination in a scarred uterus. Spontaneous rupture in the second trimester before labor is a very rare condition. Here, we report a case of uterine rupture at 23-week pregnancy due to elevated uterine pressure with a history of laparoscopic myomectomy one year before admission. She was symptomatic for diffuse abdominal pain and the ultrasonographic image was interpreted as amniotic band. Four days later, because of deterioration of the patient and fetal bradycardia urgent laparotomy was performed. Fundal rupture with fibrotic borders suggested that a chronic event was seen. Laparoscopic myomectomy has advantages over laparatomy but the possibility of uterine rupture in following pregnancies should not be underestimated. Therefore, repair of the myometrium should be carefully assessed.
Uterine Rupture,Uterien Myomectomies,laparoscopy,Midtrimester
https://www.ijfs.ir/article_45198.html
https://www.ijfs.ir/article_45198_9b1f2857c04b4b6e8a25be571a415262.pdf
Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)
International Journal of Fertility and Sterility
2008-076X
2008-0778
7
3
2013
10
01
Three-Dimensional Image of A Communicating Uterus
243
244
EN
Firoozeh
Ahmadi
f_ahmadi@royaninstitute.org
Hadieh
Haghighi
https://www.ijfs.ir/article_45199.html
https://www.ijfs.ir/article_45199_120dff3e20bf95c05fac4d3f49b5e851.pdf