ORIGINAL_ARTICLE
Premature Ovarian Failure: A Critical Condition in The Reproductive Potential with Various Genetic Causes
Premature ovarian failure (POF) is identified as a heterogeneous disorder leading to amenorrhea and ovarian failure before the age of 40 years. The first known symptom of the disease is having irregular menstrual periods. The phenotype appearance of POF depends significantly on the variations in hormones. Low levels of gonadal hormones (estrogens and inhibins) and increased level of gonadotropins [luteinizing hormone (LH) and Follicle stimulating hormone (FSH)] (hypergonadotropic amenorrhea) are well documented as causes of POF. There is an association between the failure of germ cell development and complete ovarian failure, and consistently decreased number of germ cells is more likely associated with partial ovarian failure resulting in secondary amenorrhea. A literature review on recent findings about POF and its association with genomic alterations in terms of genes and chromosomes. POF is a complex heterogeneous disorder. Some of POF cases are carriers of a single gene mutation inherited in an autosomal or X-linked manner while a number of patients suffer from a chromosome abnormality like Turner syndrome in mosaic form and manifest secondary amenorrhea associated with ovarian dysgenesis. Among many of the known involved genes in POF development, several are prove to be positively associated to the disease development in different populations. While there is a promising association between X chromosome anomalies and specific gene mutations with POF, genome-wide analysis could prove a powerful tool for identifying the most important candidate genes that influence POF manifestation.
https://www.ijfs.ir/article_45215_fc7648e57fb1553b4392738945522ef1.pdf
2014-04-01
1
12
Premature Ovarian Failure
infertility
Amenorrhea
Farkhondeh
Pouresmaeili
pouresfar@gmail.com
1
Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical
LEAD_AUTHOR
Zahra
Fazeli
2
Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
ORIGINAL_ARTICLE
Hysterosalpingographic Appearances of Female Genital Tract Tuberculosis: Part II: Uterus
Female genital tuberculosis remains as a major cause of tubal obstruction leading to infertility, especially in developing countries. The global prevalence of genital tuberculosis has increased during the past two decades due to increasing acquired immunodeficiency syndrome. Genital tuberculosis (TB) is commonly asymptomatic and it is diagnosed during infertility investigations. Despite of recent advances in imaging tools such as computed tomography (CT) scan, magnetic resonance imaging (MRI) and ultrasongraphy, hysterosalpinography has been considered as the standard screening test for evaluation of tubal infertility and as a valuable tool for diagnosis of female genital tuberculosis. Tuberculosis gives rise to various appearances on hysterosalpingography (HSG) from non-specific changes to specific findings. The present pictorial review illustrates and describes specific and non-specific radiographic features of female genital tuberculosis in two parts. Part I presents specific findings of tuberculosis related to tubes such as "beaded tube", "golf club tube", "pipestem tube", "cobble stone tube" and the "leopard skin tube". Part II will describe adverse effects of tuberculosis on structure of endometrium and radiological specific findings, such as "T-shaped" tuberculosis uterus, "pseudo-unicornuate "uterus, "collar-stud abscess" and "dwarfed" uterus with lymphatic intravasation and occluded tubes which have not been encountered in the majority of non-tuberculosis cases.
https://www.ijfs.ir/article_45216_9201ff3ce176219dbdeef594ee33c879.pdf
2014-04-01
13
20
Female Genital Tuberculosis
Hysterosalpingography
Endometrium
Firoozeh
Ahmadi
1
AUTHOR
Fatemeh
Zafarani
fzafarani@royaninstitute.org
2
LEAD_AUTHOR
Gholam Shahrzad
Shahrzad
3
AUTHOR
ORIGINAL_ARTICLE
Selection of Sperm Based on Hypo-Osmotic Swelling May Improve ICSI Outcome: A Preliminary Prospective Clinical Trial
Background The intra-cytoplasmic sperm injection (ICSI) technique selects sperm according to morphology and motility. However, these parameters cannot predict the chromatin integrity of sperm. Considering the detrimental effects of DNA-damaged sperm on reproductive outcomes, novel sperm selection procedures have been proposed to circumvent the possibility of inseminating DNA-damaged sperm. It has been shown that different potential hypo-osmotic swelling test (HOST) patterns possess the potential to differentiate between sperm that have intact or damaged chromatin. Therefore, for the first time, this preliminary study evaluates the role of HOST as a sperm selection procedure in a clinical setting. Materials and Methods In this preliminary prospective clinical trial study, we divided infertile couples diagnosed with male infertility into two groups. In the treatment group (n=39), half of the oocytes were inseminated by sperm selected following density gradient centrifugation (DGC group). The remaining oocytes from the treatment group were inseminated by sperm chosen according to HOST pattern (c, d or e) following DGC processing (HOST group). In the control group (n=63), all oocytes were inseminated by sperm chosen after DGC. Results There was a significantly higher percentage of embryos that had good quality, implantation, and chemical pregnancy rates in the HOST group compared to the DGC group (p≤0.05). Conclusion : This study has shown that selecting sperm according to membrane functionality (HOST pattern) rather morphology and viability may open a new window in our approach for determining the appropriate sperm for ICSI, particularly in individuals with severe male infertility (Registration Number: IRCT201307087223N2).
https://www.ijfs.ir/article_45217_fa76cd842ab61a93fce5a9ad2e2bcbec.pdf
2014-04-01
21
28
host
ICSI
Fertilization
implantation
Pregnancy
Nasim
Charehjooy
1
Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran;Department of Biology, Damghan Branch, Islamic Azad University, Damghan
AUTHOR
Mohammad Hassan
Najafi
2
Isfahan Fertility and Infertility Center, Isfahan, Iran
AUTHOR
Marziyeh
Tavalaee
3
Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
AUTHOR
Mohammad Reza
Deemeh
4
Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran;Isfahan Fertility and Infertility Center, Isfahan, Iran
AUTHOR
Leila
Azadi
5
Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
AUTHOR
Abdol Hossein
Shiravi
6
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
AUTHOR
Mohammad Hossein
Nasr-Esfahani
mh.nasr-esfahani@royaninstitute.org
7
Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran;Isfahan Fertility and Infertility Center, Isfahan, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles
Background: Our objective was to evaluate the effect of ovarian endometrioma on ovarian stimulation outcomes in in vitro fertilization cycles (IVF). Materials and Methods: In this prospective cohort study, we followed 103 patients who underwent intra-cytoplasmic sperm injection (ICSI) procedures over a 24-months period. The study group consisted of 47 infertile women with either unilateral or bilateral ovarian endometrial cysts of less than 3 cm. The control group consisting of 57 patients with mild male factor infertility was candidate for ICSI treatment during the same time period as the study groups. Both groups were compared for number of oocytes retrieved, grades of oocytes, as well as embryo quantity and quality. Results: Our results showed similar follicle numbers, good embryo grades (A or B) and pregnancy rates in the compared groups. However, patients with endometrioma had higher gonadotropin consumption than the control group. The mean number of retrieved oocytes in patients with endometrioma was significantly lower than control group (6.6 ± 3.74 vs. 10.4 ± 5.25) (p < 0.001). In addition, patients with endometrioma had significantly lower numbers of metaphase II (MII) oocytes (5 ± 3.21) than controls (8.2 ± 5.4) (p < 0.001). In patients with unilateral endometrioma, there were no significant differences in main outcome measures between normal and involved ovaries in the patients with endometrioma. Conclusion: Patients with ovarian endometrioma had poor outcome. They showed poor ovarian response with lower total numbers of retrieved oocytes and lower MII oocytes during the stimulation phase; however, it does not affect the total number of embryos transferred per patient, quality of embryos, and pregnancy rate per patient.
https://www.ijfs.ir/article_45218_2187f96b8e5380ab665dc6dcedb8af6b.pdf
2014-04-01
29
34
Endometrioma
ovulation induction
In vitro fertilization
Pregnancy Rate
Mahnaz
Ashrafi
ashrafim@royaninstitute.org
1
Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran;Department of Obstetrics and Gynecology, Iran Unive
LEAD_AUTHOR
Taravat
Fakheri
tfakheri@yahoo.com
2
Department of Obstetrics and Gynecology, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Kiandokht
Kiani
3
Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran;4Vali-e-Asr Reproductive Health Research Center, Te
AUTHOR
Maria
Sadeghi
mariasadeghy@yahoo.com
4
Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
AUTHOR
Mohammad Reza
Akhoond
5
5Statistics Department, Mathematical Science and Computer Faculty, Shahid Chamran University, Ahwaz, Iran
AUTHOR
ORIGINAL_ARTICLE
Chromosomal Abnormality in Men with Impaired Spermatogenesis
Background: Chromosomal abnormalities and Y chromosome microdeletions are regarded as two most frequent genetic causes associated with failure of spermatogenesis in the Caucasian population. Materials and Methods: To investigate the distribution of genetic defects in the Romanian population with azoospermia or severe oligozoospermia, karyotype analysis by G-banding was carried out in 850 idiopathic infertile men and in 49 fertile men with one or more children. Screening for microdeletions in the azoospermia factor (AZF) region of Y chromosome was performed by multiplex polymerase chain reaction (PCR) on a group of 67 patients with no detectable chromosomal abnormality. The results of the two groups were compared by a two-tailed Fisher’s exact test. Results: In our study chromosomal abnormalities were observed in 12.70% and 8.16% of infertile and fertile individuals respectively. Conclusion: Our data suggests that infertile men with severe azoospermia have higher incidences of genetic defects than fertile men and also patients from any other group. Infertile men with normal sperm present a higher rate of polymorphic variants. It is important to know whether there is a genetic cause of male infertility before patients are subjected to intracytoplasmic sperm injection (ICSI) or testicular sperm extraction (TESE)/ICSI treatment.
https://www.ijfs.ir/article_45219_8c00af110eda6ef51c0a28ac2019bdeb.pdf
2014-04-01
35
42
Chromosomal abnormality
Chromosome Microdeletion
Male infertility
Azoospermia
Oligozoospermia
Dana
Mierla
dana_mierla@yahoo.com
1
Life Memorial Hospital, Bucharest, Romania;Department of Genetics, Faculty of Biology, University of Bucharest, Bucharest, Romania
LEAD_AUTHOR
Dumitru
Jardan
2
Life Memorial Hospital, Bucharest, Romania
AUTHOR
Veronica
Stoian
3
Department of Genetics, Faculty of Biology, University of Bucharest, Bucharest, Romania
AUTHOR
ORIGINAL_ARTICLE
Effect of Leptin on In Vitro Nuclear Maturation and Apoptosis of Buffalo (Bubalus bubalis) Oocyte
Background: Leptin, as a 16 kDa adipokine, is a pleiotropic cytokine-like hormone that primarily secreted from adipose tissue. It also involves in the regulation of energy homeostasis, neuroendocrine function, immunity, lipid and glucose homeostasis, fatty acid oxidation, angiogenesis, puberty and reproduction. The aim of this study was to investigate the effects of in vitro addition of leptin to in vitro maturation (IVM) medium on buffalo oocyte maturation and apoptosis. Materials and Methods: In this experimental study, Ovaries from apparently normal reproductive organs of slaughtered adult buffaloes (Bubalus bubalis) with unknown breeding history were collected from Urmia Abattoir, Urmia, Iran, and were transported immediately to the laboratory in a thermos flask containing sterile normal saline with added antibiotics. Oocytes were aspirated from 2-8 mm visible follicles of the ovaries using an 18-G needle attached to a 10 ml syringe. IVM medium included tissue culture medium-199 (TCM-199), 10% fetal bovine serum (FBS), 22 µg/ml sodium pyruvate, 0.5 IU/ml ovine follicle-stimulating hormone (oFSH), 0.5 IU/ml ovine luteinizing hormone (oLH), 1 μg/ml oestradiol, 50 μg/ml gentamycin, and leptin [0 (control), 10, 50, and 100 ng/ml]. The good quality buffalo oocytes (batches of 10 oocytes) were placed in a culture plate containing six 50 μl droplets of maturation medium, covered with sterilized mineral oil, and then incubated at 38.5˚C with 5% CO2 in air for 24 hours. The maturation of oocytes was evaluated under a stereomicroscope by detecting the first polar body extrusion of oocytes. FITC-Annexin V propidium iodide (PI) staining method was used to detect oocyte apoptosis. Results: From a total of 115 collected ovaries, 1100 oocytes were recovered among which 283 oocyte were suitable for IVM. In the groups of leptin treated with 0 (control), 10, 50 and 100 ng/ml, the percentage of oocytes maturation was 74.65, 83.81, 77.85, and 75.40%, while the percentage of oocytes apoptosis was 9.83, 9.54, 9.93, and 10.42%, respectively. Our results showed that addition of 10 ng/ml leptin to buffalo IVM medium increased oocyte maturation, significantly, as compared with that in control group. However, addition of leptin to IVM medium had no significant influence on buffalo oocyte apoptosis. Conclusion: Our findings suggested that addition of 10 ng/ml leptin to IVM medium of buffalo oocyte can improve oocyte nuclear maturation. Furthermore, we showed that there is no relation between in vitro addition of leptin to buffalo oocyte IVM medium and oocyte apoptos Conclusion: Our findings suggested that addition of 10 ng/ml leptin to IVM medium of buffalo oocyte can improve oocyte nuclear maturation. Furthermore, we showed that there is no relation between in vitro addition of leptin to buffalo oocyte IVM medium and oocyte apoptosis.
https://www.ijfs.ir/article_45220_2600112e21991bf7e4407fd7fb2bbfbf.pdf
2014-04-01
43
50
Buffalo
Oocyte
Leptin
maturation
Apoptosis
Amir
Khaki
a.khaki@urmia.ac.ir
1
Department of Clinical Sciences, Division of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
LEAD_AUTHOR
Rouzali
Batavani
2
Department of Clinical Sciences, Division of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
AUTHOR
Gholamreza
Najafi
3
Department of Basic Sciences, Division of Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
AUTHOR
Hamid
Tahmasbian
4
Department of Clinical Sciences, Division of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
AUTHOR
Abolfazl
Belbasi
5
Department of Clinical Sciences, Division of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
AUTHOR
Aram
Mokarizadeh
6
Department of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Irann
AUTHOR
ORIGINAL_ARTICLE
Paraoxonase 3 Activity and The Ratio of Antioxidant to Peroxidation in The Follicular Fluid of Infertile Women
Background Paraoxonase-3 (PON3), as a high density lipoprotein (HDL)-associated lactonase, is capable of preventing the oxidative modification of low density lipoprotein (LDL). PON3 activity in follicular fluid (FF) is three times more than its activity in serum. However, the detailed role of PON3 in women’s fertility remains unknown. The aim of this study was to investigate the correlation between PON3 activity in the FF of women undergoing assisted reproductive technique (ART), in vitro fertilization (IVF), or intra-cytoplasmic sperm injection (ICSI). Materials and Methods This cross-sectional study consisted of 50 women from couples with male factor infertility (MFI) or with female factor infertility (FFI). The FF samples were obtained during the ART intervention. PON3 activity, HDL cholesterol (HDL C), total antioxidant status (TAS) and the level of malondialdehyde (MDA) were determined. The morphology of the embryo was determined using embryo cell number (ECN) and embryo fragmentation score (EFS). In addition, fertilization rate (FR) was used an oocyte fertilization index. Results Of 50 women, 20 women belonged to FFI group and the remaining 30 women belonged to MFI group. PON3 activity in FF of women in FFI group was significantly lower (p < 0.05) in comparison with corresponding value in MFI group. The value of PON3 activity/MDA in the FFI group was lower than that in MFI group. Moreover, MDA level in the FF of FFI group was significantly higher (p < 0.05) than its concentration in MFI group. Meanwhile, no significant difference was found in HDL-C concentration and TAS of both groups. No significant correlation was observed between the ECN and FF biochemical parameters. There was also a negative correlation between FR and MDA (r=-0.42, p=0.02), whereas a positive relation between FR with PON3 activity (r=0.59, p=0.004), HDL-C (r=0.35, p=0.04) and PON3/MDA (r=0.59, p=0.001). Conclusion According to the results of this study, PON3 activity level as a key component of antioxidant system in FF may directly be associated with the success rate of ART and fertilization rate in women.
https://www.ijfs.ir/article_45221_15e62b1f04d1ec0d2ee08f2fd6ce0fd1.pdf
2014-04-01
51
58
infertility
PON3
follicular fluid
Peroxidation
Fertilization
Mohammad-Reza Rashidi
Rashidi
1
Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Jalal
Eisa-Khaje
2
Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Laya
Farzadi
3
Women’s Reproductive Health Research Center, Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Masoud
Darabi
4
Department of Biochemistry and Clinical Laboratories, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Alieh
Gasemzadeh
5
Women’s Reproductive Health Research Center, Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Vahideh
Shahnazi
6
Women’s Reproductive Health Research Center, Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Shabnam Fayezi
Fayezi
7
Students Research Committee, Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Amir
Mehdizadeh
8
5Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
Reza
Haji Hosseini
9
6Department of Biology, Payame Noor University, Tehran, Iran
AUTHOR
Mohammad
Nouri
nourimd@yahoo.com
10
7Umbilical Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Variations in T-helper 17 and Regulatory T Cells during The Menstrual Cycle in Peripheral Blood of Women with Recurrent Spontaneous Abortion
Background: Disorders in immune system regulation may result in pregnancy abnormalities such as recurrent spontaneous abortion (RSA). This study aims to determine the ratio of regulatory T (Treg) and T helper (Th) 17 cells in unexplained RSA (URSA) women during proliferative and secretory phases of their menstrual cycles compared to healthy non-pregnant women. Materials and Methods: In this case control study, 25 women with URSA and 35 healthy, non-pregnant women were enrolled. The percentage of Th17 and Treg cells in participants peripheral blood were determined by flow cytometry. Results: The percentage of Th17 cells and their related cytokines in serum (IL-17A) were higher in the proliferative and secretory phases of the menstrual cycles of URSA women compared to the control women. However, a lower percentage of Treg cells and their related cytokines in serum, transforming growth factor (TGF) β1 and interleukin (IL)-10 were detected in the proliferative but not the secretory phase of the URSA group. The ratio of Th17/CD4+ Treg was higher in the URSA group than the control group. We observed an increased ratio of Th17/CD4+ Treg during the proliferative and secretory phases in URSA women. Conclusion: The imbalance between Th17 and Treg cells during the proliferative phase of menstrual cycles in the URSA group may be considered a cause for spontaneous abortion.
https://www.ijfs.ir/article_45222_556c7e293e4fb44fc886d9dd91369ae5.pdf
2014-04-01
59
66
Regulatory T Cells
T Helper 17
Menstrual Cycle
Pregnancy
Nasrin
Sereshki
1
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Marjan
Gharagozloo
2
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Vajihe
Ostadi
v.ostadi@gmail.com
3
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Ataollah
Ghahiri
4
Department of Obstetrics and Gynecology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Mohammad Ali
Roghaei
roghaei@med.mui.ac.ir
5
Department of Obstetrics and Gynecology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Ferdos
Mehrabian
6
Department of Obstetrics and Gynecology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Alireza Andalib
Andalib
7
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Akbar
Hassanzadeh
8
School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Habibolla
Hosseini
9
4Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Abbas
Rezaei
rezaei@mui.ac.ir
10
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
The Effect of Marital Violence on Infertility Distress among A Sample of Turkish Women
Background: The aim of this study was to determine the relationship between marital violence and distress level among women with a diagnosis of infertility. Materials and Methods: This cross-sectional study consisted of 139 married women diagnosed as primary infertile who applied to an in vitro fertilization (IVF) center in Turkey, between September and December 2009. A descriptive information questionnaire developed by the researcher was used for data collection. In addition, an infertility distress scale (IDS) for determining the severity effect of infertility and the scale for marital violence against women (SDVW) for determining level of marital violence against the women were used. Results: The total IDS score of the study sample was 37.76 ± 10.53. There was no significant relationship between the age and education level of the women and the total IDS score. The total IDS score was higher in women who did not work and those being treated for infertility for more than three years. The total SDVW score of the study sample was 67.0 ± 8.26. The total SDVW score was higher in women who had been trying to have a child for more than six years and had received infertility treatment for longer than three years. The employment status of the women and physical, emotional, and sexual violence scores had a statistically significant relationship with the IDS scores. The emotional violence score was found to have the highest significance among the variables affecting total IDS score. Conclusion: Marital violence is a factor increasing the distress of infertile women. Healthcare staff serving infertile couples should consider the possibility of domestic violence against women as a factor affecting the psychological infertility distress level.
https://www.ijfs.ir/article_45223_3faeaf13c03b3cbe7fca5cd9918f91c5.pdf
2014-04-01
67
76
infertility
Violence
Distress
Aygül
Akyüz
aygulakyuz@yahoo.com
1
Department of Obstetrics and Gynecologic Nursing, Koc University School of Nursing, Istanbul, Turkey
LEAD_AUTHOR
Gönül
Şahiner
2
Department of Obstetrics and Gynecologic Nursing, Gulhane Military Medical Academy, School of Nursing, Ankara, Turkey
AUTHOR
Memnun
Seven
3
Department of Obstetrics and Gynecologic Nursing, Koc University School of Nursing, Istanbul, Turkey
AUTHOR
Bilal
Bakır
4
Department of Public Health, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey
AUTHOR
ORIGINAL_ARTICLE
Effect of Pertubation on Pregnancy Rates before Intrauterine Insemination Treatment in Patients with Unexplained Infertility
Background: The aim of this study was to determine the relationship between marital violence and distress level among women with a diagnosis of infertility. Materials and Methods: In this prospective randomized study, a total of 180 patients were included in the study. Amongst these, pertubation of the uterine cavity was carried out in 79 patients prior to insemination. One patient in the pertubation group was later excluded because insemination could not be performed due to cycle cancellation. Results: There were no significant differences in demographic characteristics between the study and control groups. When the pregnancy rates of both groups were evaluated, 14(17.8%) patients in the study group achieved pregancy. Three (3.8%) had a biochemical pregnancy, 1(1.3%) miscarried and 10(12.7%) had live births. In the control group, a total of 24(23.8%) pregnancies were achieved, amongst which one (1%) had a biochemical pregnancy, 3(3%) miscarried and 20(19.8%) resulted in live births. There was no significant difference between groups in terms of total pregnancy and live birth rates (p > 0.05). There was a 21% total pregnancy loss rate. There was no significant difference between the control and study groups in terms of pregnancy loss rates (p > 0.05). Conclusion: This study on a homogenous group of unexplained infertile patients determined that the addition of pertubation to a controlled ovarian hyperstimulation plus intrauterine insemination (COH+IUI) treatment protocol did not affect pregnancy rates (Registration Number: NCT01999959).
https://www.ijfs.ir/article_45224_d1e2b6e32a5dcb74231fdbdde1067dae.pdf
2014-04-01
77
84
Pertubation
Gonadotrophin
Unexplained infertility
Funda
Yildiz
dr.fundakorkmaz@mynet.com
1
LEAD_AUTHOR
Nuray
Bozkurt
2
AUTHOR
Ahmet
Erdem
3
AUTHOR
Mehmet
Erdem
4
AUTHOR
Mesut
Oktem
5
AUTHOR
Recep
Onur Karabacak
6
AUTHOR
ORIGINAL_ARTICLE
Simultaneous Serous Cyst Adenoma and Ovarian Pregnancy in An Infertile Woman
Ovarian pregnancy is a rare form of extra uterine pregnancy. Serous cyst adenoma is a benign variant of epithelial cell tumors of ovary. The coexistence of a cyst adenoma with an ovarian pregnancy in the same ovary is extremely rare. Some studies suggested that infertility or ovulation-inducing drugs can be involved in increased risk of ovarian tumors and ovarian pregnancies. A 28-year-old infertile woman presented with a ruptured ovarian pregnancy following ovulation induction with metformin. She had a concurrent benign serous cyst adenoma in the same ovary. Resection of both ovarian pregnancy and tumoral mass were performed. The ovary was preserved. Removal of gestational tissue and preservation of the involved ovary are the best options for management of ovarian pregnancy in young patient. Although there is an association between infertility/ovulation inducting medications and ovarian gestation, their connections with serous cyst adenoma are undetermined.
https://www.ijfs.ir/article_45225_5cfc314857dd47f711d4c1934b84e1d4.pdf
2014-04-01
85
90
infertility
ovulation induction
Ectopic pregnancy
Ovarian Pregnancy
Metformin
Mahbod
Ebrahimi
maeb214@yahoo.com
1
LEAD_AUTHOR
Firoozeh
Akbari Asbagh
2
AUTHOR
ORIGINAL_ARTICLE
Laparoscopic Fertility Sparing Management of Cervical Cancer
Fertility can be preserved after conservative cervical surgery. We report on a 29-year-old woman who was obese, para 0, and diagnosed with cervical insufficiency at the first trimester of current pregnancy due to a previous trachelectomy. She underwent laparoscopic transabdominal cervical cerclage (LTCC) for cervical cancer. The surgery was successful and she was discharged two days later. The patient underwent a caesarean section at 38 weeks of gestation. Laparoscopic surgery is a minimally invasive approach associated with less pain and faster recovery, feasible even in obese women.
https://www.ijfs.ir/article_45226_e6ddce49a14cb6eb159700ce3226daa8.pdf
2014-04-01
91
94
laparoscopy
cervical cancer
Cerclage
Pregnancy
Trachelectomy
Chiara
Facchini
1
The Minimally Invasive Gynecological Surgery Unit, Department of Gynecology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
AUTHOR
Giuseppina
Rapacchia
2
Department of Obstetrics and Gynecology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
AUTHOR
Giulia
Montanari
3
The Minimally Invasive Gynecological Surgery Unit, Department of Gynecology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
AUTHOR
Paolo
Casadio
4
The Minimally Invasive Gynecological Surgery Unit, Department of Gynecology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
AUTHOR
Gianluigi
Pilu
pilu@aosp.bo.it
5
Department of Obstetrics and Gynecology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
AUTHOR
Renato
Seracchioli
renato.seracchioli@aosp.bo.it
6
The Minimally Invasive Gynecological Surgery Unit, Department of Gynecology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
LEAD_AUTHOR
ORIGINAL_ARTICLE
Chromosome Duplication (14q) and The Genotype Phenotype Correlation
The rearrangement of chromosome 14 is a rare cytogenetic finding. Changes in the number or structure of chromosome 14 can have a variety of effects, such as delayed growth and development, and distinctive facial features. The human chromosome 14 plays an important role in imprinting events importunes of a structural rearrangement is specifically when a phenotype is caused by imprinting, whereby the interpretation of genotype-phenotype correlation becomes extremely difficult. In this study, we examined a 3 year-old mentally impaired girl with unusual facial features. G-banding showed terminal duplication of chromosome 14 in the karyotype of the patient. In this particular case, we explained a phenotype genotype correlation in a patient with a dup (14) rearrangement, thus emphasizing the importance of prenatal diagnosis for pregnancies with an abnormal nuchal translucency.
https://www.ijfs.ir/article_45227_be999651c9d01ca5d5cb3f33631167b2.pdf
2014-04-01
95
98
Chromosome Duplication
Mental Retardation
Chromosome 14
Ariane
Sadr-Nabavi
sadrnabavia@mums.ac.ir
1
Department of Medical Genetic, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, Iran;Medical Genetic Research Center (MGRC), S
LEAD_AUTHOR
Morteza
Saeidi
2
4Department of Neurology, Mashhad University of Medical Sciences, Ghaem hospital, Mashhad, Iran
AUTHOR
ORIGINAL_ARTICLE
A FSH-Secreting Pituitary Macroadenoma Causing A Testosterone Deficiency Syndrome
FSH-secreting pituitary adenomas can affect sexual and reproductive function. In this article, we have reported the case of a 32-year-old male with secondary infertility. The patient had sexual and reproductive disturbances. The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels. Based on previous hormonal results, the patient received pituitary stimulation and human chorionic gonadotropin (hCG) tests. Both follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed low response during the pituitary stimulation test. The results of the hCG test indicated that T/E2 could recover to a normal level. In addition, this patient was diagnosed with pituitary macroadenoma, which was supported by the pituitary MRI. The man’s sexual and reproductive functions recovered following surgery. The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining. The purpose of this report was to review the relative literature and discuss the influence of FSH-secreting pituitary adenomas on hormones through the hypothalamus-pituitary-testis axis.
https://www.ijfs.ir/article_45228_852c335a3c175ff462e3a997534b3ee4.pdf
2014-04-01
99
104
infertility
Pituitary Adenoma
Semen analysis
Xiong
Wang
1
Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China
AUTHOR
Li
Ge
2
Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China
AUTHOR
Yuanqing
Cui
3
Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China
AUTHOR
Cuihong
Lang
4
Weifang Maternal and Child Health Hospital, Shandong, China
AUTHOR
Cuifang
Hao
cuifanghao@aliyun.com
5
Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China
LEAD_AUTHOR