%0 Journal Article %T Association of Interleukin-17A rs2275913 Polymorphism with Recurrent Miscarriage: A Systematic Review and Meta-Analysis Study %J International Journal of Fertility and Sterility %I Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR) %Z 2008-076X %A Keshavarz Motamed, Atoosa %A Zarei, Zhina %A Mirfakhraee, Hosna %A Shariatinia, Fatemeh %A Akbari, Malihe %A Ziagham, Sara %A Igder, Somayeh %A Zarei, Neda %D 2023 %\ 11/01/2023 %V 18 %N 1 %P 7-11 %! Association of Interleukin-17A rs2275913 Polymorphism with Recurrent Miscarriage: A Systematic Review and Meta-Analysis Study %K IL-17A rs2275913 %K Polymorphism %K recurrent miscarriage %R 10.22074/ijfs.2023.546127.1248 %X Recurrent miscarriage (RM) is a condition defined as having three or more consecutive pregnancy losses before the20 weeks of pregnancy. The present study was undertaken to investigate association of Interleukin-17A (IL-17A)rs2275913 polymorphism with RM. To this end, we searched the international databases (Web of Science, PubMed,Embase, and Scopus) and extracted studies investigating the association of IL-17A rs2275913 polymorphism withRM using the appropriate keywords. The collected data were analyzed with the random-effects model and STATA(version 14). A total of five studies met the eligibility criteria, and total sample size was 998 subjects. Mean ageof the cases and controls were 31.41 ± 4.16 and 30.56 ± 3.5 years, respectively. Our results disclosed a significantrelationship of the IL-17A rs2275913 AA genotype [odds ratio (OR)=1.68; 95% confidence interval (CI)=1.16-2.43; I2=19; P=0.294) with RM. There was no statistically significant correlation between IL-17A rs2275913 GGgenotype (OR=1.04; 95% CI=0.64-1.7; I2=59.5; P=0.042) and GA genotype (OR=0.85; 95% CI=0.65-1.12; I2=19.1;P=0.293) with RM. Our findings revealed that the IL-17A rs2275913 polymorphism is associated with RM, and theAA genotype of this polymorphism increased possibility of being involved in RM. %U https://www.ijfs.ir/article_704705_32ec579cda5158acdae1dd3bdc4ae5a9.pdf