%0 Journal Article %T Evaluating the Role of First Polar Body Morphology on Rates of Fertilization and Embryo Development in ICSI Cycles %J International Journal of Fertility and Sterility %I Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR) %Z 2008-076X %A Halvaei, Iman %A Khalili, Mohammad Ali %A Soleimani, Mehrdad %A Razi, Mohammad Hossein %D 2011 %\ 07/01/2011 %V 5 %N 2 %P 110-115 %! Evaluating the Role of First Polar Body Morphology on Rates of Fertilization and Embryo Development in ICSI Cycles %K First Polar Body %K Oocyte Morphology %K ICSI %K Fertilization Rate %K Embryo Development %R %X Background Recent studies have demonstrated that morphology of the first polar body (1stPB) is related to oocyte viability, which can be used as a prognostic tool to predict oocyte performance and pregnancy outcomes in an intracytoplasmic sperm injection (ICSI) program. According to some studies, there is a correlation between oocyte performance and 1stPB morphology, while others have not reported any correlation. The objective of this study is to evaluate the role of 1stPB morphology on rates of fertilization and embryo development in ICSI cases. Materials and Methods In this prospective study morphological characteristics of 470 metaphase II (MII) oocytes were assessed in 80 ICSI cycles. The women were ages 21-42 years (mean 32.6 ± 0.2). Their oocytes were retrieved after a hyperstimulation protocol. After denudation, all oocytes were evaluated for 1stPB morphology. The oocytes were divided into two groups of A (normal 1st Results Twenty-seven percent of oocytes had fragmented 1stPB, while the remainder was associated with other morphological abnormalities. A total of 46.1% and 26.9% of oocytes showed double and multiple defects, respectively. RF was the most common abnormality observed in group B. No significant differences in women’s’ ages between groups A and B were noted (p=0.3). A total of 179 and 107 oocytes (61.5% vs. 59.8%) were fertilized in groups A and B, respectively (p=0.7). The rates of good embryo formation for A and B groups were 66.5% and 55.6% (p=0.07), and cleavage rates were 77.7% and 68.5%, respectively (p=0.09). Conclusion The data demonstrated that 1stPB morphology does not appear to be a prognostic factor for rates of fertilization and embryo development in ICSI cycles. %U https://www.ijfs.ir/article_45092_a087c6ab95572de8644bb61967fdff1d.pdf