@article { author = {Barra, Fabio and Ferro Desideri, Lorenzo and Leone Roberti Maggiore, Umberto and Gaetano Vellone, Valerio and Maramai, Mattia and Scala, Carolina and Ferrero, Simone}, title = {Endometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target}, journal = {International Journal of Fertility and Sterility}, volume = {14}, number = {1}, pages = {76-77}, year = {2020}, publisher = {Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)}, issn = {2008-076X}, eissn = {2008-0778}, doi = {10.22074/ijfs.2020.5876}, abstract = {In the recent original research published on International Journal of Fertility and Sterility the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and endometriosis in 150 Iranian patients suffered this disease. The authors notably found a lower frequency of TNF-α -863C/A allele A among the affected patients in comparison with healthy women, although this difference was not significant by adjusting multiple testing. We deem that the authors should specify, if these patients had peritoneal nodules, ovarian endometrioma/deep infiltrating endometriosis (DIE) nodules or combination of them, since it has been hypothesized that these phenotypes may represent three distinct pathogenetic entities of endometriosis.}, keywords = {Endometriosis,Genetic polymorphisms,Tumor Necrosis Factor,Alpha}, url = {https://www.ijfs.ir/article_45583.html}, eprint = {https://www.ijfs.ir/article_45583_e3e3f4b334c4927c367489d3ce05d0f6.pdf} }