@article { author = {Sereshki, Nasrin and Gharagozloo, Marjan and Ostadi, Vajihe and Ghahiri, Ataollah and Roghaei, Mohammad Ali and Mehrabian, Ferdos and Andalib, Alireza Andalib and Hassanzadeh, Akbar and Hosseini, Habibolla and Rezaei, Abbas}, title = {Variations in T-helper 17 and Regulatory T Cells during The Menstrual Cycle in Peripheral Blood of Women with Recurrent Spontaneous Abortion}, journal = {International Journal of Fertility and Sterility}, volume = {8}, number = {1}, pages = {59-66}, year = {2014}, publisher = {Royan Institute, Iranian Academic Center for Education Culture and Research (ACECR)}, issn = {2008-076X}, eissn = {2008-0778}, doi = {}, abstract = {Background: Disorders in immune system regulation may result in pregnancy abnormalities such as recurrent spontaneous abortion (RSA). This study aims to determine the ratio of regulatory T (Treg) and T helper (Th) 17 cells in unexplained RSA (URSA) women during proliferative and secretory phases of their menstrual cycles compared to healthy non-pregnant women. Materials and Methods: In this case control study, 25 women with URSA and 35 healthy, non-pregnant women were enrolled. The percentage of Th17 and Treg cells in participants peripheral blood were determined by flow cytometry. Results: The percentage of Th17 cells and their related cytokines in serum (IL-17A) were higher in the proliferative and secretory phases of the menstrual cycles of URSA women compared to the control women. However, a lower percentage of Treg cells and their related cytokines in serum, transforming growth factor (TGF) β1 and interleukin (IL)-10 were detected in the proliferative but not the secretory phase of the URSA group. The ratio of Th17/CD4+ Treg was higher in the URSA group than the control group. We observed an increased ratio of Th17/CD4+ Treg during the proliferative and secretory phases in URSA women. Conclusion: The imbalance between Th17 and Treg cells during the proliferative phase of menstrual cycles in the URSA group may be considered a cause for spontaneous abortion.}, keywords = {Regulatory T Cells,T Helper 17,Menstrual Cycle,Pregnancy}, url = {https://www.ijfs.ir/article_45222.html}, eprint = {https://www.ijfs.ir/article_45222_556c7e293e4fb44fc886d9dd91369ae5.pdf} }