Past Issue

Volume 14, Number 1, Apr-Jun 2020 Pages: 76-77

Endometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target

Fabio Barra, M.D, 1, 2, *, Lorenzo Ferro Desideri, M.D, 1, 2, Umberto Leone Roberti Maggiore, Ph.D, 1, 2, Valerio Gaetano Vellone, M.D, 3, Mattia Maramai, M.D, 1, 2, Carolina Scala, Ph.D, 1, 2, Simone Ferrero, Ph.D, 1, 2,
Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy
Department of Surgical and Diagnostic Sciences, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
*Corresponding Address: Academic Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa Italy


In the recent original research published on International Journal of Fertility and Sterility the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and endometriosis in 150 Iranian patients suffered this disease. The authors notably found a lower frequency of TNF-α -863C/A allele A among the affected patients in comparison with healthy women, although this difference was not significant by adjusting multiple testing. We deem that the authors should specify, if these patients had peritoneal nodules, ovarian endometrioma/deep infiltrating endometriosis (DIE) nodules or combination of them, since it has been hypothesized that these phenotypes may represent three distinct pathogenetic entities of endometriosis.