Past Issue

Volume 7, Number 4, Jan-Mar 2014, Pages: 331-336

Serum Adiponectin Level and Clinical, Metabolic, and Hormonal Markers in Patients with Polycystic Ovary Syndrome


Yunus Yildiz, M.D., Gülnur Ozaksit, M.D., Bekir Serdar Unlu, M.D., *, Emre Ozgu, M.D., Hasan Energin, M.D., Metin Kaba, M.D., Mustafa Ugur, M.D.,
* Corresponding Address: P.O.Box: 100710 Department of Obstet-rics and Gynecology Zekai Tahir Burak Women Health Education and Research Hospital Ankara Turkey Email: drserdarunlu@yahoo.com

Abstract

Background:

To investigate the relationship between adiponectin, metabolic and hor- monal parameters, and insulin resistance in patients with non-treated polycystic ovary syndrome.

Materials and Methods:

In this cross-sectional observational study, 81 patients admitted to out-patient clinic with complaints of menstrual irregularity, hirsutism and obesity were enrolled. Serum adiponectin, biochemical and hormonal parameters, and 75 gram oral glu- cose tolerance test (OGTT) were measured. Spearman’s correlation coefficient was used for statistical analysis.

Results:

We observed inverse correlations between serum adiponectin level and body mass index, homeostasis model assessment insulin-resistance score, insulin level, fast- ing glucose level, and prolactin level (p=0.001, p=0.02, p=0.04, p=0.02, and p=0.005, respectively). No significant correlations were found between serum adiponectin level and age, height, weight, Ferriman-Gallwey score, 2 hours OGTT test value and free tes- tosterone level (p=0.3, p=0.6, p=0.2, p=0.8, p=0.9, and p=0.01, respectively).

Conclusion:

The present study demonstrated that in polycystic ovary syndrome patients, when serum adiponectin level decreased, degree of insulin resistance increased. Our find- ings indicate that serum adiponectin level is likely to be an adequate marker for deter- mination of the degree of insulin resistance, and may be a predictor of diseases, such as type 2 diabetes mellitus (T2DM) and metabolic syndrome, which develop on the basis of insulin resistance.