Journal Title: Volume 4, Number 1, Apr-Jun 2010 , Pages: 1-44
Page From: 29 To: 34
Article title: Hysteroscopic Subendometrial Embryo Delivery (SEED), Mechanical Embryo Implantation
Background: A major hurdle to improved in vitro fertilization (IVF) success rate is defective
endometrial receptivity and implantation. Various techniques have been advocated to increase
implantation while reducing side effects. Currently, embryo transfer (ET) is performed blindly
without direct visualization. As such, we sought to develop a technique utilizing a flexible minihysteroscope
with a flexible catheter for direct implantation of the blastocyst(s).
Materials and Methods: This was a case study performed at West Coast IVF Clinic, Inc., Beverly
Hills, California 90212. A total of 15 IVF Cycles in 13 patients (average age = 29) underwent
visually directed ET and endometrial implantation. All women received luteal support.
The main outcome measure in this study, both clinically and procedurally, was the relevant
development and assessment of a novel surgical technology.
Results: In this study, eight (60%) pregnancies ensued [5 (62.5%) clinical and 3 (37.5%)
biochemical]. Of note, there was no uterine scratching, uterine bleeding, or ectopic pregnancies.
Significantly, high-order pregnancies were decreased; only one twin was conceived.
Conclusion: Preliminary data suggest mechanically assisting implantation with a hysteroscopic
blastocyst ET (SEED) offers a viable option for improving pregnancy outcome.
Endometrium, ART, In vitro Fertilization, SEED
International Journal of Fertility and Sterility
Vol 4, No 1, Apr-Jun 2010, Pages: 29-34
|Michael Kamrava, M.D ||First Authoremail@example.com|
|Mei Yin, M.Sc. ||Other Author|