Platelet-rich fibrin lysate (PRF-L) is a promising solution to enhance pregnancy outcomes in women with thin endometrium undergoing in vitro fertilization: a proof-of-concept study of clinical trial

Articles in Press

Document Type : Original Article

Authors

1 Infertility Department, Hung Vuong Hospital, Ho Chi Minh City, Viet Nam Department of Physiology and Animal Biotechnology, Biology and Biotechnology Faculty, VNUHCM-University of Science, Viet Nam

2 Department of Obstetrics and Gynecology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam

3 Infertility Department, Hung Vuong Hospital, Ho Chi Minh City, Vietnam

4 Department of Physiology and Animal Biotechnology, Biology and Biotechnology Faculty, VNUHCM-University of Science, Viet Nam Laboratory of Tissue Engineering and Biomedical Materials, VNUHCM-University of Science, Viet Nam Vietnam

10.22074/ijfs.2024.2020043.1610

Abstract

Background: This study aims to investigate the preliminary result of platelet-rich fibrin lysate (PRF-L) intervention in improving endometrial thickness and enhancing in vitro fertilization (IVF) outcomes for patients with a thin endometrium, particularly those who showed no response to platelet-rich plasma (PRP).

Materials and Methods: This open-label, phase I clinical trial, approved by the Ethical Committee of the University of Medicine and Pharmacy, Ho Chi Minh city (reference number 265/HĐĐĐ-ĐHYD), was carried out at Hung Vuong Hospital from July 2022 to May 2023. Among the 561 patients undergoing their first IVF cycle, we identified three patients who experienced failure in at least two consecutive endometrial preparations for frozen embryo transfer (FET) cycles due to a thin endometrium (measuring less than 7 mm) and showed no response to PRP treatment. These three patients were selected to undergo PRF-L intervention. We recorded pre- and post-intervention endometrial thickness measurements and pregnancy outcomes.

Results: While both PRP and PRF-L contributed to improvements in endometrial thickness, the intervention with PRF-L resulted in greater increases in endometrial thickness and a higher rate of pregnancies, even among patients who showed no response to PRP.

Conclusion: The findings demonstrated more favorable results with PRF-L compared to PRP. Further research should continue exploring the potential applications of PRF-L in IVF.

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International Journal of Fertility and Sterility

Articles in Press, Accepted Manuscript
Available Online from 08 May 2024

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