Evaluation of Ovarian Reserve by Measurement of the Serum Levels of Anti-Mullerian Hormone and Follicle-Stimulating Hormone in Intracytoplasmic Sperm Injection Cycles
Background It is important to evaluate ovarian reserves prior to intracytoplasmic sperm injection (ICSI) treatment. The aim of this study is to determine the accuracy of anti-mullerian hormone (AMH) as a marker for ovarian reserve and to compare it with day-3 serum follicle-stimulating hormone (FSH) levels.
Materials and methods In this analytic, corss-sectional study, sequential sampling was done on 70 infertile women who underwent ICSI treatment at Imam Khomeini Hospital, Ahvaz, Iran. Initially, 5cc of venous blood was drawn from each patient to measure serum AMH and FSH levels on the day-3 cycle. Patients were divided into two subgroups according to the numbers of oocytes retrieved. Patients were classified as good responders if there were four or more oocytes retrieved, whereas patients with less than four oocytes were poor responders.
Results The basal AMH level correlated with the number of oocytes retrieved (linear Pearson correlation coefficient=0.599), however the basal FSH level had a weakly reverse correlation (correlation coefficient = -0.11). AMH levels had a sensitivity of 85% and specificity of 61.5%, with a cutoff value equal to 2.3 ng/ml which was higher than FSH.
Conclusion AMH serum levels are good predictors of ovarian reserve in comparison with FSH.
Nikbakht, R., Borhani, M., & Yazdani Sarvestani, G. (2010). Evaluation of Ovarian Reserve by Measurement of the Serum Levels of Anti-Mullerian Hormone and Follicle-Stimulating Hormone in Intracytoplasmic Sperm Injection Cycles. International Journal of Fertility and Sterility, 4(2), 57-60. doi: 10.22074/ijfs.2010.45824
MLA
Roshan Nikbakht; Mehrdad Borhani; Gita Yazdani Sarvestani. "Evaluation of Ovarian Reserve by Measurement of the Serum Levels of Anti-Mullerian Hormone and Follicle-Stimulating Hormone in Intracytoplasmic Sperm Injection Cycles". International Journal of Fertility and Sterility, 4, 2, 2010, 57-60. doi: 10.22074/ijfs.2010.45824
HARVARD
Nikbakht, R., Borhani, M., Yazdani Sarvestani, G. (2010). 'Evaluation of Ovarian Reserve by Measurement of the Serum Levels of Anti-Mullerian Hormone and Follicle-Stimulating Hormone in Intracytoplasmic Sperm Injection Cycles', International Journal of Fertility and Sterility, 4(2), pp. 57-60. doi: 10.22074/ijfs.2010.45824
VANCOUVER
Nikbakht, R., Borhani, M., Yazdani Sarvestani, G. Evaluation of Ovarian Reserve by Measurement of the Serum Levels of Anti-Mullerian Hormone and Follicle-Stimulating Hormone in Intracytoplasmic Sperm Injection Cycles. International Journal of Fertility and Sterility, 2010; 4(2): 57-60. doi: 10.22074/ijfs.2010.45824